Role of ADAM8 in tumor metastasis / 中国药理学通报

Tumor metastasis is one of the important biological characteristics of malignant tumor,which is closely related with the prognosis of the cancer patients.High expression of ADAM8 in varieties of tumors was revealed in many recent studies,and such aberrant expression played a crucial role in regulating of tumor metastasis.Studies showed that overexpression of ADAM8 attenuated the intercellular adhesion effect,promoted tumor angiogenesis,and enhanced the degradation of ECM as well as the releasing of cytokines.Therefore,suppression of ADAM8 may lead to inhibition of tumor metastasis,which makes ADAM8 a particular attractive target as it can be used as a prognostic indicator and a potential therapeutic target of malignant tumor.A review about the relations between ADAM8 protein′s abnormal expression and tumor occurrence was discussed in this paper,also include discussion about the mechanisms of ADAM8 protein′s disorder-induced tumor formation,as well as therapeutic strategies based on ADAM8-targeted,which may provide references for follow-up research and clinical treatment.

Research progress in preclinical cancer models / 肿瘤

Along with the increase in incidence and mortality of cancer, cancer has become a threat to human health. Therefore, more and more researchers have devoted themselves to the exploration of the pathogenesis of cancer and the related new therapies. Even so, only a few new anticancer drugs have been approved every year, the main reason is that the vast majority of new drugs has better preclinical effect but not has good clinical curative effect, so the reasonable application and innovation of preclinical evaluation system of antineoplastic drugs and the combination and unification of preclinical studies and clinical efficacy are urgent and important. It is well known that animal cancer models play an important role in the pathogenesis and treatment of cancer. This paper discusses the prospect of the most commonly used mouse models of cancer in preclinical studies and the challenges, and introduces the prospect of the new cancer models, in order to provide references for rational evaluation of clinical efficacy of drugs.

The Mechanism Study of Micro-substance of Chinese Medicine——The Discovery and Elucidation of Effective Substance and Mechanism of Chinese Medicine via the Theory of Synthetic Lethality / 世界科学技术-中医药现代化

The elaboration of the mechanism and pharmacodynamic substance are the main obstacles to the modernization of Chinese medicine.The rich ingredient of Chinese medicine is almost attention,with a research strategy of forward pharmacology.This strategy often neglects the study of trace components of Chinese medicine.Synthetic lethality,a extremely complex gene interactions,is to magnify the effects of the co-regulation of biological effects (＞ 1 000 times).The theory of synthetic lethality has achieved good results in the development of anti-tumor drugs,including the discovery of PARP inhibitors,the clinical use of chemotherapy drug addition and attenuation combination.In view of this,this research model may be used to elucidate trace effective substance.Based on the reverse thinking of "targetcomponent-effect"and clear synergistic targets,the mechanism of traces and weak-potency substance of traditional Chinese medicine was studied,and the synergistic combination of potential was found.

Research progress on relationship between glucose transporter 1 and tumor energy metabolism / 中国药理学通报

The study on tumor metabolism has been gradually be-come a hot spot in recent years .A lot of proteins involved in the regulation of tumor metabolism especially the glucose transporter protein 1(GLUT1).As a key regulatory factor mediating energy metabolism within tumor cells , GLUT1 can regulate the glucose intake and maintain the basic level of metabolism in tumor cells . More importantly, the abnormal expression of GLUT1 was asso-ciated with many kinds of tumors , of which GLUT1 was used to meet the energy requirement for the fast growth of tumor .Thus GLUT1 also played a crucial role in growth , differentiation and metastasis of tumor cells and prognosis of tumors .Meanwhile , as three-dimensional crystal structure of GLUT 1 was determined , it is possible to design the small molecular inhibitors of GLUT 1, which can realize “starve to death” tumor cells.GLUT1 can be a particularly attractive target for tumor treatment and interfer-ence.The relationship between abnormal expression of GLUT 1 protein and tumor metabolism was reviewed . Moreover , the mechanism of tumor metabolism regulated by GLUT 1 protein ex-pression and treatment of cancers were discussed , which may provide references for future research and clinical treatment .

Ultrasound diagnosis types of placenta previa during the late pregnancy and its relationship with the perinatal outcome / 中国医师进修杂志

Objective To investigate ultrasound diagnosis different types of placenta previa (PP)during the late pregnancy and its relationship with the perinatal outcome.Methods The clinical data of 170 pregnant women with PP and 170 healthy pregnant women who underwent ultrasound were retrospectively analyzed.PP-related risk factors were analyzed,the perinatal outcome of different types of PP were compared.Results Among PP pregnant women,complete PP was in 82 cases,partial PP was in 36 cases,marginal PP was in 32 cases,low-lying placenta was in 20 cases.The rate of age ＞ 30 years old,parity,gravidity,the number of abortion and the number of cesarean section in PP pregnant women were significantly higher than those in healthy pregnant women [59.4％(101/170) vs.40.0％(68/170),(1.5 ± 0.6) times vs.(1.3 ± 0.4) times,(2.4 ± 0.5) times vs.(1.7 ± 0.1) times,(1.7 ± 0.1) times vs.(1.1 ± 0.3) times,(1.3 ±0.3) times vs.(1.0 ± 0.1) times,P ＜ 0.01].Parity,gravidity,the number of abortion,the number of cesarean section,age,and the incidence rate of cesarean section,postpartum hemorrhage,placental adherence,premature delivery,neonatal weight ＜ 2.5 kg,5 min Apgar score ＜ 7 scores in complete PP pregnant women were significantly higher than those in partial PP,marginal PP and low-lying placenta pregnant women (P＜0.01).Conclusions Ultrasound can dynamically observe the development process of the PP.There is a certain correlation with the severity of risk factors of PP,early intervention can improve the prognosis.