Formulation, evaluation and release rate characteristics of medicated jelly of vitamin C

Medicated jelly formulations are patient friendly dosage form for pediatric, geriatric and dysphagic patients. These formulations offer rapid dissolution and absorption of drugs through oral mucosa therefore show the early onset of action. The objective of the study was to develop and evaluate oral jelly formulations of vitamin C. Slurry method was adopted using glucose 103gm, sugar 67gm, gelatin 10gm and sorbitol 6.56gm. Preformulation studies were performed including the organoleptic profile, pH, and solubility of both drugs. The medicated jelly of Vitamin C was prepared and evaluated for physical characteristics, weight variation, syneresis, pH, taste and palatability, drug content, release rate characteristics and stability studies. All the jellies were found to have patient welcoming taste and were palatable. All formulations showed more than 50% drug release within 15 minutes, while 93% drug was released in 30 minutes. The results of release kinetics showed that the formulation followed the zero order release kinetics. Thus the drug was released at constant rate independent of the drug concentration involved in the process. All the medicated jellies were found to remain stable stored for 60 days at different temperatures. The present study revealed that medicated jellies of vitamin C could be employed orally in an effective form as an alternative solid oral dosage form for special population such as pediatrics, geriatrics and patients with dysphagia

Effect of partial replacement of different defatted oil seed cakes as substrate in biosynthesis of bacitracin in solid-state fermentation by bacillus licheniformis

The present study was conducted to ascertain the effect of partial replacement of different defatted oil seed cakes as substrate i.e. sunflower meal, rice hulls and soybean meal, in biosynthesis of Bacitracin in Solid-State fermentation by Bacillus licheniformis on laboratory scale. In solid-state fermentation, wheat bran, soybean meal, sunflower meal, rice hulls and their different combinations were used. The antibiotic activity was determined at various intervals and recorded 48 hours gave maximum yield, 4375 i.u/gm when only soybean was used. However, maximum titre 4820 i.u/gm of antibiotic were obtained when wheat bran and soybean meal was in ratio of 1:3. The raw material for its production is readily available and cheap such as soybean meal, sunflower meal and wheat bran. Thus development of this technology in our country would result in utilizing our own resources in Pakistan

Antibiotic resistance pattern gramong gram-negative bacteria isolated from raw milk in multan

The use of raw milk in Pakistan has led to the antibiotics resistance. This investigation has showed incidence and antibiotic resistance among Coliform and Klebsiella to nalidixic acid, urixin and little to chloramphenicol. Enterobacter was sensitive to nalidixic acid, tetracycline and showed little resistance to chloramphenicol. E. coli were very sensitive to nalidixic acid, tetracycline, chloramphenicol, urixin, amoxil and with no resistance to ceftriaxone