RESUMO
Background: Several studies have reported improper ionic environment in cardiovascular and renal patients but how the diseases are associated on ionic basis is still not clear
Objective: The present study was aimed to investigate sodium and potassium concentrations and their transport abnormalities in cardiovascular and renal patients
Patients and Methods: Thirty patients of various cardiovascular and thirty patients of various renal disorders [53.33% males, 46.67% females] were selected. Erythrocytes were isolated from freshly drawn blood samples, washed and used for the estimation of sodium and potassium levels using flame photometer [Corning 410]. Serum sodium and potassium were measured by flame photometer. RBC membranes were prepared for the estimation of Na[+] -K[+] -ATPase activity in terms of inorganic phosphate released/mg protein/hour
Results: Intra-erythrocyte and serum sodium and potassium concentrations and Na[+] -K[+] -ATPase activity were different in cardiovascular and renal patients from controls. Intra-erythrocyte sodium level was increased significantly [P<0.01] in cardiovascular patients and non-significantly in renal patients as compared to controls. Na[+] -K[+] -ATPase activity and serum sodium level were decreased significantly [P<0.01] in both the groups as compared to controls. Serum potassium was found to be decreased significantly [P<0.01] in cardiovascular patients whereas it was raised significantly [P<0.01] in renal patients as compared to control subjects
Conclusion: The results indicated similar nature of ionic and electrolyte imbalances in cardiovascular and renal disorders resulting from impaired Na[+] -K[+] -ATPase system. Further investigations in the same area, may be of help to establish an understanding of the progression of diseases, associated complications and the preventive steps that should be taken to arrest the progression of these disorders
RESUMO
Rabbits of both sexes were injected with indomethacin 10 mg/kg. One hour after injections blood was analzed for serum electrolytes and osmolality. Administration of indomethacin caused increase in serum sodium [p<0.01], potassium [p<0.01], calcium [p<0.05], phosphorous [p<0.01]. chloride [p<0.01] and glucose [p<0.01] in both sexes. Two way ANOVA showed a significant treatment effect on sodium [p<0.01], potassium [p<0.01], calcium [p<0.01], phosphorus [p<0.05] and chloride [p<0.01]. It is concluded that the ingestion of indomethacin can have a major effect on serum electrolytes and osmolality, that may influence the clinical data in patients taking this drug. The present study on the serum electrolytes balance show a possible involvement of greater increase of serum potassium, calcium, phosphorus and chloride concentration in male than in similarly treated female rabbits, because of the slow absorption capacity of this drug in females