Synthesis, reactions and anticancer activity of some new heterobicylic nitrogen systems bearing acenaphtho [1,2-e] [1,2,4] triazine moiety, part I

Some new heterobicylic nitrogen systems, e.g. acetonitrile derivatives bearing acenaphtho [1,2-e] [1,2,4] triazine moiety have been synthesized and reacted with hydrazine hydrate, acetohydrazide, acids, alkalis, thiosemicarbazide and carbon disulphide. Structural assignment of the synthesized products 2-19 were confirmed by elemental analyses and spectral data [[1]H-NMR and [13]C-NMR determinations]. Some selected compounds showed remarkable anticancer activity

Synthesis, reactions and anticancer activity of some new heterobicylic nitrogen systems bearing acenaphtho[l,2-e] [l,2,4] triazine moiety, part II

Some new heterocycles bearing acenaphtho [l,2-e][1,2,4] triazine moiety were synthesized via condensation of N-[acnaphtho[l,2-e][l,2,4]triazin-9-yl] formamide [2] with nitrogen and oxygen reagents. Structural assignment of the synthesized products 2-16 were confirmed by elemental analyses and [1]H-NMR and [13]C-NMR determinations. Screening for some selected compounds showed remarkable anticancer activity

Synthesis and anticancer activity of some acenaphtho [1,2-e] [1,2,4]-triazinotriazine derivatives

Some new fused heterobicydic nitrogen systems such as acenaphtho [1,2-e] [1,2,4] triazinotriazine derivatives 2-16 have been synthesized via heterocyclization reactions upon treatment of acenaphtho[1,2-e][1,2,4]triazin hydrazide [1] with bifunctional oxygen and halogen compounds. Structural assignment of the synthesized products 2-16 was confirmed by elemental analyses and spectral data [[1]H-NMR and [13]C-NMR determinations]. Some selected compounds were screened and showed remarkable anticancer activity

Synthesis, reactions and antifungal agents of 2-[1-benzoylamino-2-[naphthyl-and/or 2 2-furyl] vinyl 4-H-3,1 benzoxazin-4-ones derivatives

The reactivity of on N-[2-naphthalen-1 or 2-furan-2]-yl-1-[4-oxo-4H-benzo[d] [1, 3]oxazin- 2-yl]-vinyl]-benzamide [3a, b] towards the nitrogen and carbon nucleophiles, led to the direct formation of heterobicyclic nitrogen compounds. Structure of the newer synthesized products [3-25] was confirmed by elemental analysis as well as by studying of their spectral data [IR. [1]H-NMR and [B]C-NMR]. Some of the target selected synthesized compounds showed remarkable anifungal activity

Synthesis and behaviour of 2-carboxyvinyl-6,8-dibromo-4H-3,1- benzoxazin-4- one towards nitrogen, carbon, and sulphur nucleophiles

3-[6, 8-DIBROMO-4-oxo-4H-benzo[d][1, 3] oxazin-2-yl]- acrylic acid [1] was synthesized and allowed to react with some nitrogen nucleophiles namely, 4-methylaniline, hydroxylamine hydrochloride, ethanolamine and glycine afforded 3-substituted quinazolinones 2-5. while with isobutylamine and benzylamine gives benzamide derivatives 6a and 6b. Compound 3 was subjected to acylation and alkylation resulting in 7 and 8, respectively. Also, compound 4 was utilized to alkylate some aromatic systems namely, 2-naphthol and benzamide to give 9a and 9b. Treatment of benzoxazinonone 1 with ophenylenediamine in different solvents under different conditions: furnished a substituted benzamide 10 and 3-substituted-quinazolinone 11. Benzoxazinone 1 was converted to 4[3H]-quinazolinone 12 by treatment with formamide and/or ammonium acetate which was alkylated with ethylchloroacetate yielded 13, which in turn reacted with hydrazine hydrade produced the hydrazide 14. Interaction of compound 1 with hydrazine hydrate gave the unexpected product fused quinazolinone 15, which was confirmed by its interaction with acid chlorides namely, acetyl and benzoyl chloride affording 16 and 17, respectively. Oxazinone ring cleavage occurred by the use of active methylene containing compounds under different conditions, thioglycolic acid, thiophenol, and thiosemicarbazide yielded 18 - 22. An interesting heterocyclization occurred by treatment of 22 with diethylmalonate producing the pyrimidindione 23

Some factors affecting ureolytic activities in Aspergillus fumigatus and Fusarium nivalis

Governing the cultural conditions of Ashergiilus fumigatus and Fusarium nivale led to significant differences in the growth and subsequently ureolytic activities either in the culture media or in the assay reaction mixtures of both species. Glucose was found to be the most suitable carbon source but its optimum concentration varied in both fungi. It was 6% in As fumigatus and 4% in F. nivale. Considering nitrogen sources, urea when used as a sole nitrogen source, was accompanied with higher growth and ureolysis in the two fungi than when any of the other tested nitrogenous compounds added. The optimum urea concentration was 6.5 glL in A. fumigatus and 4.5 g/L F. nivale. Among the different phosphate compounds tested, [NH4]2 HPO4at 1g PO4[3]-/L Was the most favourable for maximum crease [s] activities and growth in both fungi. Not only sulphate concentration was different in the test fungi, but also its source varied. [NH4] 2SO[2] at 0.5 gSO42+/L was optimum for A. fumigatus growth and ureolysis, while MgSO4 at 0.3 g SO4[2]-/L was the optimum in F. nivale