RESUMO
Cushing's disease in children is not rare but in infants it is quite rare and an important medical condition needing proper line of investigations and management options. Craniopharyngioma as a cause of Cushing's disease is well reported and practical inference of the condition is of clinical importance. Craniopharyngioma generally affects children at 5 - 10 years of age and is rarely seen in infancy. It usually manifests as endocrinological deficits such as short stature, delayed puberty, and obesity. We report the case of a 7 months old infant who presented with obesity and Cushing's disease associated with Craniopharyngioma
RESUMO
Twenty patients with infantile spasms were treated with ACTH. 18 cases [90%] had severly abnormal EEG and 2 cases [10%] had relatively milder EEG abnormality. Mental retardation was present in 19 cases [95%], most of them [85%] having this before the start of seizures, only one case [5%] had normal development even during seizures. Thirteen patients [65%] had complete control of seizures with ACTH therapy. 4 patients [20%] responded initially but soon showed recurrence. 3 patients [15%] did not respond at all. Nine patients [45%] developed side effects. Only 4 [20%] had serious but manageable side effects of hypertension and hypokalemia