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1.
Artigo em Coreano | WPRIM | ID: wpr-203052

RESUMO

In 2009, the novel swine H1N1 influenza (SI) virus infection had been pandemic and in some patients it led to death. But autopsy findings with pathologic features have been rarely known in the deceased with the SI infection. Herein we presented the findings in three deceased cases with the infection of SI virus, compared with those of other literatures. In all cases, postmortem examination with legal autopsy was done due to sudden unexpected death. SI virus infection was confirmed by detection of SI viral RNA performed on Korea center for Disease Control and Prevention. The autopsy findings with pathologic features of our cases were similar to those of the cases on other reports and those of previous pandemic influenza virus infection on literatures. And these findings may be helpful for understanding the biology of SI virus, and for diagnosis, treatment, and prevention of the SI infection.


Assuntos
Humanos , Autopsia , Biologia , Vírus da Influenza A Subtipo H1N1 , Influenza Humana , Coreia (Geográfico) , Orthomyxoviridae , Pandemias , RNA Viral , Suínos , Vírus
2.
Artigo em Inglês | WPRIM | ID: wpr-203057

RESUMO

Cerebral cavernous angioma is a rare form of vascular malformations which is histologically composed of closely-packed, thin-walled blood vessels without neural tissue intervened. One of the most common symptoms is seizure, which is usually well-controlled by medication or surgery and known to be rarely intractable or fatal. Because sudden, unexpected death in epilepsy patients reveals generally its unclear death mechanism and negative autopsy finding in forensic pathology practice, particular attention should be paid. We recently experienced an autopsy case of 32-year-old woman who had suffered from epilepsy and showed cerebral cavernous angioma on autopsy. We report this case with literature review.


Assuntos
Adulto , Feminino , Humanos , Autopsia , Vasos Sanguíneos , Cavernas , Sistema Nervoso Central , Epilepsia , Patologia Legal , Hemangioma , Hemangioma Cavernoso , Convulsões , Malformações Vasculares
3.
Artigo em Coreano | WPRIM | ID: wpr-227717

RESUMO

Alzheimer's disease is the leading cause of dementia. We experienced a case of Alzheimer's disease who is 83-year-old woman killed by stab with a knife. She had been suffered from dementia for several years. At autopsy, the brain disclosed cortical atrophy in the frontal, temporal and parietal lobes, and hippocampus. Microscopically, many senile plaques and a few neurofibrillary tangles were observed at the cerebral cortex and hippocampus. Senile plaques were characterized by a spherical structure with or without a dense central core of amyloid, associated with dystrophic neurites. Neurofibrillary tangle was an intracellular filamentous lesion in the cell body of neuron. To our knowledge, this is a rare autopsy case in Korea, therefore, we report here-in and review the clinicopathologic features of Alzheimer's disease.


Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Doença de Alzheimer , Amiloide , Atrofia , Autopsia , Encéfalo , Córtex Cerebral , Demência , Hipocampo , Coreia (Geográfico) , Neuritos , Emaranhados Neurofibrilares , Neurônios , Lobo Parietal , Placa Amiloide
4.
Artigo em Coreano | WPRIM | ID: wpr-180554

RESUMO

Pompe disease (Glycogenosis type 2) is an autosomal recessive glycogen storage disorder by deficiency of lysosomal acid alpha-glucosidase. The disorder encompasses a range of phenotypes, each including myopathy but differing in age of onset, organ involvement, and clinical severity. Glycogen storage is most prominent in skeletal and cardiac muscle, and liver. The authors described a 8-year-old girl who presented hypotonia, mental retardation and hepatomegaly, and died accidentally of burn. Light and electron microscopic examination on autopsied tissue revealed diffuse both cytoplasmic and lysosomal glycogen storage in hepatocytes, neurons of cerebral cortex and hippocampus, and renal tubular epithelium. A few cases of Pompe disease with CNS involvement has been reported in English literature previously. Nevertheless, to our knowledge, it is the first time in Korea.


Assuntos
Criança , Feminino , Humanos , Idade de Início , alfa-Glucosidases , Queimaduras , Córtex Cerebral , Citoplasma , Epitélio , Glicogênio , Doença de Depósito de Glicogênio Tipo II , Hepatócitos , Hepatomegalia , Hipocampo , Deficiência Intelectual , Coreia (Geográfico) , Fígado , Hipotonia Muscular , Doenças Musculares , Miocárdio , Neurônios , Fenótipo
5.
Artigo em Coreano | WPRIM | ID: wpr-122675

RESUMO

The Kawasaki disease(Mucocutaneous lymph node syndrome) has been reported worldwide since the first description in 1967 in Japan. Approximately 20% of the children with untreated Kawasaki disease are believed to develop coronary artery aneurysm of which 2-3% progress to coronary artery stenosis. The early mortality of Kawasaki disease is low, resulting from coronary complications, mainly aneurysmal thrombosis with myocardial infarction. The purpose of this article is to report three cases of sudden deaths who died of cardiac sequelae of Kawasaki disease. Case 1 was a 9 year old male who died of cardiac tamponade caused by ruptured left coronary artery with features of vasculitis and aneurysmal dilatation. Case 2 was a 20 year old male who had been healthy and died suddenly and unexpectedly. At autopsy, the heart showed cardiomegaly and coronary artery aneurysm with thrombus and stenosis. Case 3 was a 10 year old male who was asymptomatic. At autopsy, the heart showed coronary artery lesions including aneurysm, fibrous thickening, and calcification, and myocardial fibrosis. According to the Classification of Kawasaki disease, case 1 was considered Stage I, and cases 2 and 3 Stage IV.


Assuntos
Criança , Humanos , Masculino , Adulto Jovem , Aneurisma , Autopsia , Tamponamento Cardíaco , Cardiomegalia , Classificação , Constrição Patológica , Estenose Coronária , Vasos Coronários , Morte Súbita , Dilatação , Fibrose , Coração , Japão , Linfonodos , Mortalidade , Síndrome de Linfonodos Mucocutâneos , Infarto do Miocárdio , Trombose , Vasculite
6.
Artigo em Coreano | WPRIM | ID: wpr-148308

RESUMO

We recently encountered a rare autopsy case of neurofibromatosis type I(von Reckli- nghausen disease) associated with both Moyamoya disease and pheochromocytoma. A 36-year-old male died of subarachnoid and intracerebral hemorrhage, who had history of three times of head surgery due to head trauma since the age of 16, and abdominal surgery for inflammed granulation tissue with central abscess. On examination, he had numerous cafe au lait spots, and multiple sessile and pedunculated greysh yellow nodules varying in size on the skin of the whole body, histopathologically being proven neurofibromas. At the base of the brain, abnormal complex vascular networks were recognized around the circle of Willis. Microscopically, some of blood vessels showed eccentric intimal fibrous thickening and tortuous internal elastic lamina, a finding which is consistent with Moyamoya vessels. Also, a pheochromocytoma on right adrenal gland was incidentally found. To the best of our knowledge, this unique combination has never been reported in Korea.


Assuntos
Adulto , Humanos , Masculino , Abscesso , Glândulas Suprarrenais , Autopsia , Vasos Sanguíneos , Encéfalo , Manchas Café com Leite , Hemorragia Cerebral , Círculo Arterial do Cérebro , Traumatismos Craniocerebrais , Tecido de Granulação , Cabeça , Coreia (Geográfico) , Doença de Moyamoya , Neurofibroma , Neurofibromatoses , Neurofibromatose 1 , Feocromocitoma , Pele , Hemorragia Subaracnóidea
7.
Artigo em Coreano | WPRIM | ID: wpr-148312

RESUMO

Giant cell myocarditis is a rare rapidly fatal disease of unknown cause, often occuring in young to middle-aged adults. Most presented with congestive heart failure, ventricular arrhythmia, heart block or sudden cardiac death. The histologic hallmarks of giant cell myocarditis include a polymorphous inflammatory response with numerous multinucleated giant cells and myocyte necrosis. Response to immunosuppresive therapy is poor and cardiac transplantation is considered to be the treatment of choice. We experienced 4 cases of giant cell myocarditis, all of which were autopsied and underwent postmortem pathologic examination. Grossly, the heart was enlarged, measuring up to 510 gm, with thickend septal and ventricular wall. Microscopically, 3 cases showed diffuse active myocarditis with extensive myocyte necrosis, while 1 case showed exuberant fibrosis. Many multinucleated giant cells were present throughout the lesion. Immunohistochemical stain supports the view that the giant cells have a histiocytic origin. Neither microorganisms nor foreign material were found on PAS and AFB stains. Because giant cell myocarditis is on occasion associated wth immunologic disorders, autopsy should be carefully performed to define the correlation between the two.


Assuntos
Adulto , Humanos , Arritmias Cardíacas , Autopsia , Corantes , Morte Súbita , Morte Súbita Cardíaca , Fibrose , Células Gigantes , Coração , Bloqueio Cardíaco , Insuficiência Cardíaca , Transplante de Coração , Células Musculares , Miocardite , Necrose
8.
Artigo em Coreano | WPRIM | ID: wpr-151038

RESUMO

Pulmonary lymphangioleiomyomatosis is a rare disease which is defined as an abnormal proliferation of smooth muscles around lymphatics, venules, and bronchioles. The most frequent presenting complaint is dyspnea, either in conjunction with pneumothorax, chylothorax, or on exertion. Common extrapulmonary features are retroperitoneal adenopathy, tuberous sclerosis and renal angiomyolipomas. This case was a 34-year-old pregnant woman who died of pneumothorax. She had no past history of illness. At autopsy, both lungs showed honey-comb appearance, and was proven histopathologically pulmonary lymphangioleiomyomatosis. The proliferating smooth muscles were immunoreactive for alpha-smooth muscle actin and HMB-45. Multiple angiomyolipomas of left kidney coexisted. However, no stigmata of tuberous sclerosis was present. Pregnancy was thought to aggravate her clinical course.


Assuntos
Adulto , Feminino , Humanos , Gravidez , Actinas , Angiomiolipoma , Autopsia , Bronquíolos , Cristianismo , Quilotórax , Dispneia , Rim , Pulmão , Linfangioleiomiomatose , Músculo Liso , Pneumotórax , Gestantes , Doenças Raras , Esclerose Tuberosa , Vênulas
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