RESUMO
Both diabetic retinopathy (DR) and coronary heart disease (CHD) are clinically significant in diabetic patients. We investigated the correlation between the severity of DR and the presence and severity of CHD among type 2 diabetic patients. A total of 175 patients who were examined at the DR clinic and underwent dual-source computed tomography (DSCT) angiography within 6 months were included. The degree of DR was graded as no DR, nonproliferative DR (NPDR), and proliferative DR (PDR). The severity of CHD and the numbers of significant stenotic coronary artery on DSCT angiography according to DR grade were assessed. The mean Agatston Calcium Score (ACS) in patients with PDR was significantly higher than other groups (P < 0.001). The overall odds of an ACS increase were about 4.7-fold higher in PDR group than in no DR group (P < 0.001). In PDR group, in comparison with in no DR, the odds of having 1 or 2 arterial involvement were 3-fold higher (P = 0.044), and those of having 3 were 17-fold higher (P = 0.011). The c-index, one of the predictability values in regression analysis model, was not significantly increased when PDR was added to classical CHD risk factors (0.671 to 0.706, P = 0.111). Conclusively, patients with PDR develop a greater likelihood of not only having CHD, but being more severe nature. PDR has no additional effect to classical CHD risk factors for predicting CHD.
Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angiografia , Doença da Artéria Coronariana/complicações , Vasos Coronários/diagnóstico por imagem , Diabetes Mellitus Tipo 2/complicações , Retinopatia Diabética/complicações , Taxa de Filtração Glomerular , Modelos Lineares , Razão de Chances , Fatores de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios XRESUMO
Both diabetic retinopathy (DR) and coronary heart disease (CHD) are clinically significant in diabetic patients. We investigated the correlation between the severity of DR and the presence and severity of CHD among type 2 diabetic patients. A total of 175 patients who were examined at the DR clinic and underwent dual-source computed tomography (DSCT) angiography within 6 months were included. The degree of DR was graded as no DR, nonproliferative DR (NPDR), and proliferative DR (PDR). The severity of CHD and the numbers of significant stenotic coronary artery on DSCT angiography according to DR grade were assessed. The mean Agatston Calcium Score (ACS) in patients with PDR was significantly higher than other groups (P < 0.001). The overall odds of an ACS increase were about 4.7-fold higher in PDR group than in no DR group (P < 0.001). In PDR group, in comparison with in no DR, the odds of having 1 or 2 arterial involvement were 3-fold higher (P = 0.044), and those of having 3 were 17-fold higher (P = 0.011). The c-index, one of the predictability values in regression analysis model, was not significantly increased when PDR was added to classical CHD risk factors (0.671 to 0.706, P = 0.111). Conclusively, patients with PDR develop a greater likelihood of not only having CHD, but being more severe nature. PDR has no additional effect to classical CHD risk factors for predicting CHD.
Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angiografia , Doença da Artéria Coronariana/complicações , Vasos Coronários/diagnóstico por imagem , Diabetes Mellitus Tipo 2/complicações , Retinopatia Diabética/complicações , Taxa de Filtração Glomerular , Modelos Lineares , Razão de Chances , Fatores de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: To compare the six-month clinical outcomes of Tek-Lens II model 872 (Tekia, Inc.) and Akreos MI-60 (Bausch & Lomb, Inc.) hydrophilic aspheric intraocular lenses (IOLs) implanted in-the-bag. METHODS: After phacoemulsification was performed by a single surgeon (JY Kim), two different hydrophilic aspheric IOLs were implanted: the Tek-Lens II IOL in 57 eyes and the MI60 IOL in 49 eyes. The best corrected visual acuity (BCVA), refractive error (RE), total high-order aberration (HOA), anterior chamber depth (ACD), and contrast sensitivity (CS) were measured preoperatively and one, three, and six months postoperatively. All parameters were analyzed using the independent t-test to compare the two IOL groups. RESULTS: There was no significant difference in the BCVA, RE, or HOA between the two groups at any of the follow-up visits. Three months postoperatively, the ACD of the TEK-Lens II group as measured by corneal topography was significantly shallower than that of the MI60 group (3.67 +/- 0.52 mm vs. 4.10 +/- 0.40 mm; p = 0.008), and most of the photopic CS in the Tek-Lens II group was significantly higher than that in the MI60 group (all p < 0.05). CONCLUSIONS: The Tek-Lens II IOL showed comparable clinical outcomes with a proven hydrophilic aspheric IOL for the postoperative six months.