woman and her son with abnormal complicated anthrponotic cutaneous leishmaniasis

This paper presented a son and his mother with positive leishmaniasis IHAT [1/128 and 1/1924, respectively]. Using enzymatic electrophoresis characterization, the two isolates proved to be Leishmania tropica that causes anthroponotic cutaneous leishmaniasis [ACL]. The son had two large ulcerative ACL on his left hand. The mother had a large ulceration and progressive erosion of the soft tissue [the right cheek and right eye] and the cartilage of the nose disfigured and debilitated her face. The histopathological examination of the biopsy material obtained from the mother, but not the material from her son, showed typical pathological picture of the basal cell carcinoma

Histopathological and immunohistochemical studies of skeletal muscle in mice experimentally infected with schistosoma mansoni

Histopathological, histochemical and immunohistochemical studies were carried out on the skeletal muscles of mice experimentally infected with Schistosoma mansoni throughout 20 weeks post infection. Histopathological changes were detected from the 13th week post- infection in spite of absence of Schistosoma mansoni eggs. There were definite enzymatic changes dehydrogenase, non-specific esterase and acid and alkaline phosphatases. These changes started from the 14th week post-infection. S. mansoni immune complex deposits were detected in the muscles from the 9th week post infection. Positive correlation was found between the degree of immune complex deposition and histopathological and histochemical changes. The study confirmed the role of immune complex in the pathogenesis of skeletal muscle lesion in Schistosoma mansoni infection [schistosomal myopathy]

Vimentin expression in different types of breast carcinoma immunohistochemical study

Vimentin was preferentially expressed in medullary and high grade ductal not otherwise specified [NOS] carcinomas. In the present study, 58 cases of invasive breast carcinomas were tested for vimentin on formaldehyde fixed paraffin embedded sections. Vimentin was expressed in 14/44 [32%] of infiltrating duct carcinoma NOS. It was expressed in less than 10% of tumor cells in 5/44 [11.4%] and in >/10% of tumor cells in 4/7 [57%]. However, none of the lobular carcinoma expressed vimentin. Vimentin was expressed in 9 of 18 [50%] of grade III infiltrating duct NOS carcinoma versus 5 of 21 [24%] of grade II and 0 of 5 [0%] of grade I carcinoma. It was preferentially expressed in tumor growing in broad anastomosing bands or sheets with numerous mitoses, high nuclear grade, scanty supportive stroma and extensive necrosis