Effect of metformin and antioxidant agents on oxidative stress status and follicular maturation in women with polcystic ovary syndrome

In this study, forty-two Iraqi Arab Women with PCOS were involved and they were classified into three groups according to type of treatment:1] Group I: fourteen patients who administered metformin [500mg t.i.d]. 2] Group II: fourteen patients who administered combination of metformin [500mg t.i.d] with vitamin C [250mg t.i.d] 3] Group III: fourteen patients who administered combination of metformin [500mg t.i.d] with vitamin E [200mg t.i.d].All groups were treated for three months. The present study includes the measurement of serum malondialdehyde, Vitamin E and its metabolite [tocopheronic acid] play an important role in alleviation of oxidative stress [MDA] and may potentiate the metformin activity in maturation of follicles