Paradoxical response to antituberculous therapy

A paradoxical response in a patient infected with tuberculosis is generally defined as the clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in a patient who initially improves with anti-tuberculosis therapy. It occurs in about 5% of patients with a clinical diagnosis of Mycobacterium tuberculosis infection. Since a rapid and accurate diagnostic test is lacking, the diagnosis of this paradoxical phenomenon can only be ascertained when other differential diagnoses such as secondary infections, inadequate anti-tuberculosis therapy as a result of drug resistance, poor compliance, and adverse reactions due to therapy are excluded

interpreting physician is essential to avoid inaccurate diagnosis of PET-CT: a case report

The presence of a pulmonogist in the process of interpreting chest PET-CT is quite crucial, as the clinical findings will prevent any miss leading interpretations that result an inaccurate diagnosis