1.
Artigo
em Inglês
| IMSEAR
| ID: sea-41990
RESUMO
The result reported here represents the first human genomic screen for MSI in Epstein-Barr-Virus associated NPC. The analysis revealed the incidence of MSI only 1 of 23 cases (4%) which indicates that MSI is less common in NPC development.
Assuntos
Primers do DNA , DNA de Neoplasias/genética , DNA Viral/genética , Infecções por Herpesviridae/genética , Herpesvirus Humano 4/genética , Humanos , Repetições de Microssatélites , Neoplasias Nasofaríngeas/genética , Reação em Cadeia da Polimerase , Infecções Tumorais por Vírus/genética
2.
Artigo
em Inglês
| IMSEAR
| ID: sea-40605
RESUMO
In order to demonstrate and define possible tumor suppressor gene loci on chromosome 11 associated with NPC, we used 7 STR to test for LOH on 25 NPC samples. LOH was detected in 46 per cent of cases. Most LOH loci were clustered on the long arm. Further study demonstrated 22 per cent and 45.5 per cent of cases with LOH on 11q13 and 11q23 respectively.