RESUMO
One hundred and twenty male and female rats, 150-200 gm of body weight, were randomly divided into 4 groups and acclimatized to controlled conditions for 2 weeks. One served as a control group and the others were orally given fresh juice “Yaa Bei-jing” every day for 3 months. The dose given were 700, 1750, 3500 mg of plant per 250 gm of body weight were equal to 1, 2.5, 5 times of therapeutic dose used in man multiplied by 7. Body weight was observed every week to show their normal growths. Ten rats from each group were sacrificed every month to determine blood chemistry, CBC, pathological findings of the lungs, kidneys, livers, spleens, testes or ovaries. Up to 4, 8 and 12 weeks of experimental period, no abnormal results occurred.
RESUMO
Effects of shallot on lipid levels, platelet function and fibrinolytic activity were investigated in 17 normal volunteers (9 males, 8 females), aged 18-25 years. Complete physical examination to rule out underlying diseases have been done before performing the experiment. Blood samples were taken on admission to the program and every 2 weeks during the 4-week control period to dertermine lipid levels, blood sugar, liver and kidney functions, platelet and fibrinolytic activity. Subjects were then given shallot capsules, prepared from lyophilized fresh shallot juice, each subject received 2 capsules three times a day (equivalent to 50 gm. of fresh shallot per day) to be taken orally for a period of 6 weeks. Blood samples were taken 2 hours after the first dose, every 2 weeks and one month after stopping shallot. No significant difference between all the above parameters were found except for the fibrinolytic activity 2 hours after the first does (equivalent to 15 gm. of fresh shallot) which revealed shorter lysis time. This action may decrease the development of thromboembolism. Further studies of dosage variation, onset and duration of fibrinolytic action may be beneficial in the development of shallot as a treatment for thromboembolic disease.