RESUMO
Patients with liver cirrhosis are suffering from hemodynamic disturbances and its subsequent complications. In this study nitric oxide [NO] [serum nitrite and nitrate] is measured in three groups of patients [25 patients each] with liver cirrhosis versus a control group. Group [I] included patients with compensated liver cirrhosis, group [II] patients had decompensated liver cirrhosis and group [III] patients suffered from hepato-renal syndrome. It was found that NO was high in group [I] compared with the control, Higher in group [II] compared with the control and group [I] and highest in group [III]. With the increase of serum NO there was increase in serum interlekin-1 [one of time trigger factors for NO release]. However, no statistical positive correlation was found, with time increase of NO there was decrease in the GFR in group [III] but this negative correlation was not statistically significant. There might be a possible role of NO and IL-1 in the pathogenesis of hemodynamic disturbances found in patients with liver cell failure and those developing hepatorenal syndrome