RESUMO
Twenty three children with recurrent episodes of diarrhea and chronic malnutrition were studied for pancreatic duct function. Those children were subjected to pancreatic stimulation with pancreozymin and secretin. Grade I malnourished children, as per Gomez classification, formed the control group. The water output from pancreas increased in malnourished children (p < 0.05). It correlated significantly to cationic transport (p < 0.01). Sodium and potassium together accounted for significant proportion of water output in pancreatic fluid. Potassium transport increased with increasing severity of malnutrition and may be responsible for the hypokalemia observed in malnourished children. Pancreatic secretion of bicarbonate decreased in severe malnutrition inspite of increased flow rate of pancreatic secretion. This is probably due to defective bicarbonate secretion likely to be located at pancreatic duct epithelial cell membrane.
Assuntos
Bicarbonatos/metabolismo , Estudos de Casos e Controles , Criança , Pré-Escolar , Doença Crônica , Diarreia/complicações , Humanos , Índia , Lactente , Transporte de Íons , Ductos Pancreáticos/fisiopatologia , Desnutrição Proteico-Calórica/complicações , Análise de Regressão , Tripsina/metabolismoRESUMO
Lipid profile of sixty survivors of myocardial infarction was studied and these results were compared with hundred age and sex matched controls. Seventy one percent had normal cholesterol (Ch). However, 80% of them had elevated serum Triglyceride (Tg) values. A decreased apolipoprotein A1 (apo A1) with an increased apolipoprotein B (apo B) values were observed in these patients. Ratio of apo A1 to apo B remained significantly low in survivors of myocardial infarction. It was seen that more abnormalities in patients were observed in apolipoprotein concentrations rather than lipoprotein or lipid concentration.
Assuntos
Adulto , Idoso , Apolipoproteína A-I/sangue , Apolipoproteínas B/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , SobreviventesRESUMO
Twenty-seven live related donor renal allograft recipients were evaluated for dyslipoproteinemia. Twenty-two patients received dual immunosuppression with prednisolone and azathioprine. Five patients received cyclosporin as well. Total cholesterol (Tch), triglycerides (TG), HDL cholesterol (HDLch), LDL cholesterol (LDLch) and VLDL cholesterol (VLDLch) levels were estimated. Fifteen (56%) patients showed significant lipoprotein abnormalities. Renal allograft recipients showed significantly lower levels of Tch (p < 0.05) and LDLch (p < 0.05) and higher levels of TG (p < 0.005) and HDLch (p < 0.05). Diet and beta blockers did not influence lipoprotein levels. A significant negative correlation was noted between post-transplant duration and Tch, TG and VLDLch levels. Increased TG levels were associated with increase in weight and higher daily prednisolone dosage at the time of evaluation. The study confirms the existence of dyslipoproteinemia in renal allograft recipients.