1.
Braz. j. med. biol. res
;
22(6): 733-6, June 1989. ilus
Artigo
em Inglês
| LILACS
| ID: lil-75205
RESUMO
Intravenous injections of lipopolysaccharide (LPS, 20 microng/Kg) and of a factor originating from LPS-stimulated macrophage monolayers (Neutrophil Recruitment Inhibitory Factor, NRIF) inhibited neutrophil migration into peritoneal cavities induced by carrageenin in rats for up to 24 h. Mononuclear cell migration induced by thioglycollate was also inhibited by the same treatment with LPS but was not affected by NRIF. We conclude that NRIF specifically blocks neutrophil migration and we suggest that NRIF released into the circulation may constitute an important determinant of septicemia