RESUMO
Background: Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia
Objective: The present study aims to investigate the effect of multimineral-vitamin D supplements [calcium, magnesium, zinc and Vitamin D] and vitamins [C+ E] in the prevention of preeclampsia
Materials and Methods: In this randomized clinical trial, 90 pregnant women were divided into three groups: group A received Ferrous sulfate [1 tablet/day] + one tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous sulfate [1 tablet/day] + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily
Results: The incidence of preeclampsia in group A was significantly lower than the control group [p=0.03], while there was no significant difference between group B and controls [p=0.50], as well as groups A and B [p=0.063]. The incidence of neonatal complications in the group A was significantly lower than the control group [p=0.01], while there was no significant difference between group B and control [p=0.48]
Conclusion: According to the results, calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia