RESUMO
Our experimental study showed that in a dose related manner SP has successful inhibitory effect on the rat uterine horn, and also on the smooth muscle organs; ileum and trachea. We guess that SP can be used in well regulated dosed with least side effects to arrest preterm labor on human being in the future. Up to date there is no manuscript about contraction inhibitory effect of SP on the uterus. We hope this study will be of scientific help.
Assuntos
Animais , Dietilestilbestrol/farmacologia , Relação Dose-Resposta a Droga , Feminino , Íleo/efeitos dos fármacos , Isoxsuprina/administração & dosagem , Contração Muscular/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Ritodrina/administração & dosagem , Espironolactona/administração & dosagem , Traqueia/efeitos dos fármacos , Contração Uterina/efeitos dos fármacosRESUMO
The spontaneous contractions of the rabbit uterine horns and the human myometrial strips were stimulated by oxytocin and buserelin acetate in isolated preparations. Spironolactone application to these models produced inhibitory effects on the contractions. It is concluded that spironolactone has inhibitory effect on the rabbit uterine horn and the human myometrial strip contractions.