RESUMO
A number of crude extracts from folk medicinal plants were screened for cytotoxicity against the human T-cell leukemia cell line. Fixed aliquots from a quantified cell suspension were incubated for three days in the presence of a control and several different concentrations of the given plant extract
Assuntos
Humanos , Azadirachta , Leucemia de Células T , Plantas Medicinais , Trinidad e TobagoRESUMO
Although the values reported were higher than those reported for Caucasians, differences in dibucaine number for pseudocholinesterase values among the three ethnic groups in Trinidad and Tobago, were not significant. Eight individuals had intermediate dibucaine numbers values between 40 and 70; one of them was African, 3 were East Indians, and 4 Mixed. Two of the mixed group were of Portuguese lineage and had significantly lower dibucaine numbers and enzyme concentration. Two sisters of East Indian origin had an inestimable dibucaine number and their pseudocholinesterase values were just detectable, suggesting the presence of a 'silent gene' for pseudocholinesterase. These studies, which are being extended, suggest that the dibucaine number should be estimated prior to succinylcholine administration in patients in Trinidad and Tobago who are at risk of apnoea
Assuntos
Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , /genética , Dibucaína , Trinidad e Tobago , Grupos Raciais/genéticaRESUMO
A manual for the course "General principles of drug action"