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Acupuncture-moxibustion is remarkably effective on encephalopathy, but its mechanism is unclear. With the continuous development of imaging technology, the in vivo brain imaging technology has been used increasingly in life science research and it also becomes a more effective tool for the basic research of acupuncture-moxibustion in treatment of encephalopathy. The paper summarizes the application of its technology in the basic research of acupuncture-moxibustion for encephalopathy and the characteristics of imaging, as well as the advantages and shortcomings. It is anticipated that the references may be provided for the basic research of acupuncture-moxibustion in treatment of encephalopathy and be conductive to the modernization of acupuncture-moxibustion.
Assuntos
Humanos , Moxibustão , Terapia por Acupuntura , Acupuntura , Encefalopatias/terapia , NeuroimagemRESUMO
Depression has become a serious global public health problem due to its high incidence and great harm, and has aroused the attention of the society. Ketamine, a commonly used intravenous anesthetic and analgesic in clinical practice, has been found to have unique advantages in antidepressant therapy in recent years. With the development of research, the enantiomeric isomers of ketamine, (S)-ketamine and (R)ketamine have entered the research field of antidepressant therapy. In this paper, we reviewed the progress of research on the antidepressant effects and mechanisms of ketamine, (S )-ketamine and (R)-ketamine, and provide a brief overview of the antidepressant effects of metabolites of ketamine, thereby deepening the understanding of the readers in the field of antidepressant effects of ketamine.
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Spinal cord injury is a severe central nervous system damage. The inflammatory response plays a critical role in the secondary injury of spinal cord injury. Inflammasomes which promote the processing, maturation and secretion of interleukin (IL)-1β and IL-18 by regulating the activation of caspase-1 consequentially trigger and aggravate the inflammatory response after spinal cord injury. Targeting upstream and downstream pathways of inflammasomes to interfere with inflammatory response can significantly promote functional repair after spinal cord injury. This review will focus on the inflammasome types, the mode of activation and the treatment strategies of inflammasomes after spinal cord injury, so as to provide reference for researches on inflammation and spinal injury repair.
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Spinal cord injury is a severe central nervous system damage.The inflammatory response plays a critical role in the secondary injury of spinal cord injury.Inflammasomes which promote the processing,maturation and secretion of interleukin (IL)-1β3 and IL-18 by regulating the activation of caspase-1 consequentially trigger and aggravate the inflammatory response after spinal cord injury.Targeting upstream and downstream pathways of inflammasomes to interfere with inflammatory response can significantly promote functional repair after spinal cord injury.This review will focus on the inflammasome types,the mode of activation and the treatment strategies of inflammasomes after spinal cord injury,so as to provide reference for researches on inflammation and spinal injury repair.
RESUMO
<p><b>OBJECTIVE</b>To investigate the effect of Shuganlipi decoction on Th1/Th2 cytokines, liver function and HBV replication in patients with chronic hepatitis B (CHB).</p><p><b>METHODS</b>Eighty-six confirmed CHB cases were randomly divided into control group (n=42) and experimental group (n=44) for treatment with routine western medication and additional treatment with Shuganlipi decoction, respectively. The production of IFN-γ, IL-2, IL-6, IL-10 and liver function, HBV DNA, and HBeAg were detected in all the patients.</p><p><b>RESULTS</b>The total response rate to the treatment was significantly higher in the experimental group than in the control group (78.13% vs 57.14%, P<0.01). ALT, AST, TBIL and ALB were all improved obviously in the two groups after the treatments (P<0.01). In terms of ALT and ALB, the experimental group showed more obvious improvement than the control group(P<0.05). The treatments also resulted in significant increases of IFN-γ and IL-2 levels and reductions of IL-6 and IL-10 levels in the two groups (P<0.01).</p><p><b>CONCLUSION</b>Shuganlipi decoction can improve the liver function and activity of Th1/Th2 cytokines to promote the clearance of liver cell HBV infection.</p>