Study on the production of measles antibody used for vaccine quality control

Background: With the help of Japan, the Center for Research and Production of vaccines and biologicals, Hanoi has received a WHO standard measles vaccine production technology, including techniques in the examination of vaccine quality. Therefore, it is needed to be initiative on production of measles antibody. Objective: Study on production of measles antibody in rabbits and selecting the appropriate antibody for production of high titre antibody, which meets the standard of vaccine quality control in Vietnam. Subject and methods: Using the measles antigen from Edmonston and AIK-C strains, which were provided by the Kitasato Institute, to produce measles antibody. Making immunoreaction in rabbits and determination of neutralization antibody titre. Results and Conclusion: Measles antigen of Edmonston Vero 7/P2 strain used in the production of measles antibody in rabbit created the highest antibody titre in comparison with AIK-C strain from vero cell and FL cell supplied by the Kitasato Institute of Japan. Antibody titre of Edmonston Vero 7/P2 strain reached up to 1/8192 and met the sera standard required for measles vaccine quality control, it is similar to the measles sera to be produced from the Kitasato Institute.

Effect of the \u201cMa Tu Nhan\u201d remedy for constipation

Introduction: There are some remedies in Vietnamese traditional medicine for constipation, but most of them have not been evaluated by scientific measures. Objectives: To define the effectiveness of the \u201cMa Tu Nhan\u201d remedy for adult patients with constipation. Subjects and method: 50 patients (18 years of age or above) with constipation were given the \u201cMa Tu Nhan\u201d remedy. Constipation was defined as less than 3 times of defecation per week. The remedy included Sesanum orientale L. (500g), Semen Armeniacea (250g), Paeonia lactiflora pall (205g), Rheum sp. (500g), Magnolia officialis Rehd, et Wils (250g) and Citrus sp. (250g). The remedy was made into tablets (0.3g per tablet). Patients took 14 tablets, twice daily. The treatment period was 7 days. Results: 43 patients (86%) stopped constipations after 7 days of administration. The effect of treatment was longer behind the initial 7 days in 33 patients (66%). Conclusion: The \u201cMa Tu Nhan\u201d remedy is effective on the treatment of constipation without adverse effect.