RESUMO
Prevalence of thalassemias and/or hemoglobinopathies, particularly hemoglobin E, and cholangiocarcinoma were found more prominently in the lower part of the Northeast of Thailand as compared with the upper part of this region or any other area of the country. The aim of this study was to evaluate if there was coincident distribution or some relationship. Hemoglobin typing by the cellulose acetate method was performed in 111 cases of cholangiocarcinoma, mainly diagnosed by ultrasonography, compared with 146 normal controls. It was found that hemoglobin E trait and beta-thalassemia trait were significantly higher in the former group.
Assuntos
Adulto , Idoso , Neoplasias dos Ductos Biliares/sangue , Ductos Biliares Intra-Hepáticos , Estudos de Casos e Controles , Colangiocarcinoma/sangue , Feminino , Hemoglobina A2/metabolismo , Hemoglobina E/metabolismo , Hemoglobinopatias/complicações , Hemoglobinas/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Tailândia/epidemiologia , Talassemia beta/complicaçõesRESUMO
Low-dose ARA-C (10 mg/m2 subcutaneous injection twice/day for 20 days with 10 days rest) was prescribed in 8 cases of newly diagnosed ANLL. Only one case attained complete remission in 2 courses and lasted for one and a half years without maintenance therapy. She was 63 years of age. The drug could be tolerated well and no serious side effect was observed.