Histopathology of lymph nodes of babesia infected cattles with estimation of adenosine deaminose activity in blood cells and serum

The present work was carried out on cattles infected with Babesia bigemina. Blood examination showed various forms of the parasite intraerythrocytes. The histopathological study of the lymph nodes revealed follicular hyperplasia and marked dilatation and congestion of the medullary blood sinusoids with parasitized and non-parasitized RBCs. The activity of adenosine deaminase [ADA] was determined in erythrocytes, leukocytes and serum of infected cattles with acute babesiosis. ADA activity was significantly increased in both erythrocytes and serum, while leukocyte ADA activity showed a significant decrease indicating suppression of cell-mediated immunity

Effect of giardiasis on absorption of oral antibiotics in children and experimental animals

Intestinal absorption of oral antibiotics, in giardiasis has been studied in children and experimental animals. Serum concentrations of oral antibiotics [amoxicillin, ampicillin, cephalexin and cefaclor] were assayed in 20 children with different acute bacterial infections and concomitant presence of Giardia-lamblia in their feces with unexplained treatment failure with these antibiotics. Antigiardia therapy was given and after complete recovery from giardiasis, the initial used oral antibiotic were used again to test its absorption. Serum concentration of oral antibiotics were significantly higher after treatment of giardiasis. The experimental study was done on 2 groups of albino rats each of them was fed [amoxicillin, ampicillin, cephalexin, cefaclor, erythromycin and sulfamethoxazole. The sera were assayed for drug concentrations one hour after ingestion. The first group was infected with high dose of Giardia-lamblia, while the second group with a small dose. The results obtained showed that the mean serum concentration for all antibiotics were significantly higher before infection with Giardia-lamblia when compared to the same rats after infection. While sulfamethoxazole showed no difference