Evaluation of prevention effectiveness of intracranial hemorrhage with vitamin K injection for newborns

Background: Intracranial hemorrhage (lCH) is a common disease with high rate of mortality and neurological sequel. Objectives:to estimate preventive effectiveness of intracranial hemorrhage by vitamin K1 and K3 for newborns just after birth". Subjects and methods: An epidemiological, randomized control study with intervention was conducted. The study included all children under 3 months with and without ICH during period 1/1/2000 -30/6/2004 living in Hatay province. Among them all the newborns during period 1/6/2002 - 30/6/2004 were injected either 1 mg vitamin K1 or K3. Results: Children injected with vitamin K in the intervention period were followed up in three months and evaluated by a united process. Effects of intervention were calculated by preventive value. 62.057/82069 newborns were injected vitamin K1 or Vitamin K3 (25.725 newborns were injected Vitamin K1; 36.332 newborns were injected vitamin K3). Single dose 1M reduced the rate of ICH in infants: The morbidity changed from 3.3\ufffd?to 0.82\ufffd? the prevention value was 96%. There were no complications and side effects of vitamin K injections reported. Conclusions: Injection of vitamin K1 and K3 have similar preventive effectiveness. Vitamin K injection 1M with recommended dose was safe for newborns.\r\n', u' \r\n', u'\r\n', u'

Analyzing the characteristics of epilepsy, electroencephalographic activity and brain lesions after intracranial hemorrhage in infant

Background: The intracranial hemorrhage (lCH) in infant due to vitamin K deficiency were been informed a lot at all over the world since the year of 80's. In Viet Nam, in recent years, this disease still most occurs which account for 110-130 children/100000 alive infant. The intracranial hemorrhage (lCH) in infant causes severe neurological, psychiatric sequelae. Objectives: This study aims to analyze the characteristics of epilepsy, changing of electroencephalogram and lesions of brain after intracranial hemorrhage in infant. Subjects and method:A descriptive, cross sectional study was conducted on 97 infant patients with the age ranged from 8 days to 3 months years old whom treated in National Hospital for Peadiatric. Results: Epilepsy was common (45.3%), with generalized seizures in 24.7% , partial seizures in 20.6%. The main intracranial lesions were cerebral cyst and atrophy in right or left hemisphere or both sides. Electroencephalic activity was found impaired in most of patients: Disorder of background waves in 19.6 %, low localized waves in 31%, proxystic ativity with spike in 45.3% and decrease in electroencephalographic amplitude in cystic areas. Conclusion: The epilepsy, abnormal electroencephalographic activities, severe lesions of brain were common after intracranial hemorrhage in infant.

Some of epidemiologic characteristics of intracranial haemorrhage in children from newborn to 15 old of age on National Hospital Pediatrics

Background: Intracranial haemorrhage is a common emergency with high mortality and neurological sequelae Objectives: The aim of study were to estimate the distribution of intracranial haemorrhage between the groups of age in children and the relationship of epidemiologic characteristics to the etiology.Subjects and method: We gathered prospectively data on 621 children (0-15 ans of age) with intracranial haemorrhage in 3 years (2000, 2001, 2002) hospital records in the National Hospital Pediatrics. Results: There are annual 200 patients (0-15 ans of age) of administration. 1) Neonatal infants consisted of 97 (15,6%) patients and 35 (36,1%) of death. Some of epidemiologic characteristics associated with the etiology were premature, asphyxial over 3500 gram birth weight, interventional birth infants and infants with congenital and acquis coagulation disorders. 2) Breastfed infants consisted of 469 (75,5%) patients of administration and 52 (11,1%) of death. Infants at 29 days to 3 months of age were the most frequence (92,3%). The etiology was associated with coagulation disorders (82,9%), cholestasis (6,2%). 3)Children (1-15ans) consisted of 55 (8,9%) and 7,3% of death, specially adolescent children (7-15ans) occupied 86,3% patients in this group. The etiology could be cerebral vasculare malfmation. Conclusion: There are different distribution of administration, mortality, etiology between neonate, breastfed infants, children (1-15 ans of age)

Studying epidemiology, clinical, paraclinical characteristic of idiopathic thrombocytopenic purpura disease in National Pediatric Hospital

Background: Idiopathic or Immune Thrombocytopenic Pupura (ITP) is a common disease in Vietnamese children. This is a hemostatic disorder disease diagnosed by clinical symptoms combining with tests of platelet quantity in peripheral blood and other tests. Objectives: to study epidemiology, clinical, para-clinical characteristics and their relations in ITP disease. Subjects and methods: This was a prospective and retrospective study. The study included 579 pediatric patients from 3 months to 16 ages who were diagnosed and treated ITP disease in National Pediatric Hospital from 1/1/2003 to 12/31/2004. Results: Data were analyzed, including 191 infants from >3-<12 months (33.0%), 293 children from 1 - 10 ages (50.6%), 95 children >10-<16 ages (16.4%). The male/female ratio was highest in infants and decreased with age (P < 0.001). The disease occurred more in September, October and November with advantage factor being acute respiratory infection before 2 to 3 weeks. Subcutaneous hemorrhage ratio was highest with 557 cases (96.2%), intracranial hemorrhage happened in 7 cases (1.7%). There were differences among age groups about hemorrhage situation. Anemia level did not corresponding with the decrease of the platelet count. Conclusion: Characteristics of ITP depend on the number of platelet and age. \r\n', u'\r\n', u'\r\n', u'

Epidemiological characteristics of traffic injuries in children hospitalized in Vietnam National Hospital of Pediatrics, 2002-2005

Background: In Vietnam,every day on average at least 16 children died and more than 82 children were seriously injured by traffic accidents. Objectives: The study on epidemiological characteristics of traffic injuries in children.Subjects and method:A retrospective study of 539 children hospitalizedas a results of traffic injuries in National Hospital of Pediatrics, from january 2002 to december 2005. Results: Traffic injury hospitalization incidence rate is 0,42% (539/ 127706). Male/female was 1,46/1. Peak incidence occurs at ages 5 to 9 years. Rural children/ city children was 2,06/1. Crashes happened in october with highest frequency 12,8%, and weekend (34,8%). Motor vehicle crashes was 426 (79%). Motorcycle caused 70,4% crashes, and automobile 9,2%. 59% victims are child pedestrians.Conclusion: The traffic injury occurs commonly in children, especially in group 5-9 age. Motorcycle was the most principal vehicles occupant injuries.

Cerebral and meningeal damages in cerebral-meningeal hemorrhage in infants via brain CT imaging

During 2 years from 1998 to 1999, 76 pediatric patients underwent brain CT imaging at the Pediatric Institute. Patients aged 30-60 days and admitted with severe anemia (average of Hb 6.5+/-1.5g%). Some features of cerebral-meningeal damage in patients with cerebral-meningeal hemorrhage were showed. The most common types are subarachnoid hemorrhage (91.9%), subdural hemorrhage (74.3%), brain tissue hemorrhage (52.7%), cerebral ventricular enlargment (35.1%), lateral cerebral ventricular compression (72.4%), midle-way displacement (82.6%), cerebral oedema (96.5%). Cerebral- meningeal damage combinations included submeningeal hemorrhage alone (15.8%), subduralmeningeal hemorrhage 35.5%, submeningeal-cerebral tissue hemorrhage (48.7%).

A study on the clinical, epidemiological features of cerebral hemorrhage in infant in the hospitals in Hanoi

The morbidity rate of the cerebro- meningeal hemorrhage is high. From 1991 to 1998, the Institute of Pediatry, hospital Saint Paul and Bach Mai hospital admitted 1,325 pediatric patients with this disease in which 793 patients during 1991-1995 and 532 patients during 1996-1998. The morbidity rate in Hanoi and Ha Tay with population of 2 million was 110.5-124.15/1000.000 infant. The mortality rate was 17.2% of morbidity number. The highest morbidity occurred in the months of 9-12. Infant with 1-2 months accounted for 88.5% morbidity. Disease acquired infant with the normal history account for 91.5. The birth weight over 2.5 kg in the disease acquired infant account for 90.4%. The morbidity rate in female was higher 3 times than this in male. The infant received breast milk account for 95.7%.