Histological variants of colorectal adenocarcinoma and clinicomorphological association.

OBJECTIVE: Besides TNM staging system, some special histological features of colonic carcinomas are associated with variable clinicopathological parameters. The objective was to provide new information of correlation between various histomorphological parameters together with available clinical data and each special feature MATERIAL AND METHOD: A retrospective study of 162 materials collected from subjects with first diagnosed as adenocarcinoma of colorectum in King Chulalongkorn Memorial Hospital over a period of 2 years from 2002 to 2003. RESULT: One hundred and forty-seven cases of prominent cribiform feature are related to patient age (p = 0.025) and infiltrative margin (p = 0.006). Thirty-two cases with mucinous component are associated with patient age (p = 0.009) and tumor depth (p = 0.015). Thirteen cases with signet ring cell morphology are correlated with nodal and distant organ metastasis (p = 0.023 and p = 0.020, respectively) as well as angiolymphatic invasion (p = 0.015). In addition the size of signet ring cell containing carcinomas is also related to location (p = 0.036). It is larger in proximal site and smaller in distal counterpart. The authors did not find any statistical significance in 9 cases of medullary carcinoma. Notably, our 33 cases showed biphasic or triphasic feature. CONCLUSION: Each distinct histological variant of colorectal adenocarcinoma is associated with some different clinicopathological variables,' mostly effecting clinical outcome. Pathologists should be concerned with special histological subtypes of colorectal adeonocarcinomas and communicate with physicians for proper management.

A retrospective study of colonic polyps in King Chulalongkorn Memorial Hospital.

To evaluate and classify polyps from colon in Thai patients, the authors retrospectively analyzed the 776 polyps from 696 subjects in King Chulalongkorn Memorial Hospital during the past five-year period from 1999 to 2003. All colonic polyps were included in the study. There were 461 (59%) male and 315 (410%) female with the mean age of 51 years. Non-neoplastic and neoplastic polyps were documented 50% each. Hyperplastic polyp was the most frequent diagnosis (39%), followed by tubular adenoma (36%). According to neoplastic polyp, 8%, 3%, and 14% cases were identified as high-grade dysplastic change, intramucosal carcinoma, and invasive carcinoma, respectively.