1.
Indian J Exp Biol
;
1990 May; 28(5): 486-7
Artigo
em Inglês
| IMSEAR
| ID: sea-57642
RESUMO
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.
Assuntos
Alcaloides , Animais , Benzodioxóis , Sinergismo Farmacológico , Hipnóticos e Sedativos , Masculino , Microssomos Hepáticos/efeitos dos fármacos , Pentobarbital/administração & dosagem , Piperidinas/administração & dosagem , Alcamidas Poli-Insaturadas , Ratos , Sono/efeitos dos fármacos
2.
Hindustan Antibiot Bull
;
1984 Aug-Nov; 26(3-4): 138-9
Artigo
em Inglês
| IMSEAR
| ID: sea-2274
3.
Hindustan Antibiot Bull
;
1981 ; 23(): 6-11
Artigo
em Inglês
| IMSEAR
| ID: sea-2631