Transepidermal elimination: Historical evolution, pathogenesis and nosology

Dermoepidermal junction is the most complex structural and functional microscopic zone of the skin that enables both epidermal and dermal units to interact in many complex ways in order to perform various functions. Elimination of exogenous foreign substances or altered dermal constituents from dermis to the skin surface via epidermal channel is one of the functions of this zone which has been the mainstay in the pathogenesis of various perforating dermatoses.