1.
Genet. mol. biol
;
33(4): 610-614, 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-571528
RESUMO
The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95 percentCI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95 percentCI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified.