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1.
Journal of Korean Neuropsychiatric Association ; : 1488-1493, 1999.
Artigo em Coreano | WPRIM | ID: wpr-104564

RESUMO

OBJECTIVES: This study was designed to investigate the association between Ser311/Cys311 polymorphism in the dopamine D2 receptor gene and bipolar disorder in korean population. METHOD: Ser311/Cys311 polymorphism in the dopamine D2 receptor gene was typed with PCR in 86 bipolar disorders and 100 normal controls. RESULTS: Genotype of Ser/Ser, Ser/Cys, Cys/Cys were 82 (95.3%), 4 (4.7%), 0 (0.0%) respectively in the bipolar disorders, 96 (96.0%), 4 (4.0%), 0 (0.0%) respectively in the controls. Allele frequencies of Ser and Cys were 168 (97.7%), 4 (2.3%) in the bipolar disorders, 196 (98.0%), 4 (2.0%) in the controls. There were no differencies in genotype distribution and allele frequencies of dopamine D2 receptor gene polymorphism Ser311/Cys311 between in the bipolar disorders and in the controls. CONCLUSION: These result suggests dopamine D2 receptor gene polymorphism Ser311/Cys311 is not causally related to the development of bipolar disorder in korean population.


Assuntos
Transtorno Bipolar , Frequência do Gene , Genótipo , Reação em Cadeia da Polimerase , Receptores de Dopamina D2
2.
Journal of Korean Neuropsychiatric Association ; : 679-689, 1993.
Artigo em Coreano | WPRIM | ID: wpr-91361

RESUMO

No abstract available.


Assuntos
Humanos , Pacientes Internados
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