RESUMO
A 66 year-old obese woman with arthrosis, self-medicated with oral nimesulide, 200 mg daily. After 6 weeks she developed nausea, jaundice and dark urine. Two weeks later she had recurrent hematemesis and was hospitalized. Besides obesity and anemia her physical examination was unremarkable. An upper GI endoscopy revealed 3 acute gastric ulcers and a 4th one in the pyloric channel. Abdominal ultrasonogram showed a slightly enlarged liver with diffuse reduction in ecogenicity; the gallbladder and biliary tract were normal. Blood tests demonstrated a conjugated hyperbilirubinemia (maximal total value: 18,4 mg/dl), ALAT 960 U/l, ASAT 850 U/l, GGT 420 U/l, alkaline phosphatases mildly elevated, pro-time 49 percent and albumin 2.7 mg/dl. Serum markers for hepatitis A, B and C viruses were negative. ANA, AMA, anti-SmA, were negative. Ceruloplasmin was normal. A liver biopsy showed bridging necrosis and other signs of acute toxic liver damage. Gastric ulcers healed after conventional treatment and hepatitis subsided after 2 months leaving no signs of chronic liver damage. The diagnosis of toxic hepatitis due to nimesulide was supported by the time-course of drug usage, sex, age, absence of other causes of liver disease, a compatible liver biopsy and the improvement after drug withdrawal. Peptic ulcers or toxic hepatitis have been previously described as independent adverse reactions in patients taking nimesulide or other NSAIDs but their simultaneous occurrence in a single patient is a unique event that deserves to be reported
Assuntos
Humanos , Feminino , Idoso , Anti-Inflamatórios não Esteroides/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/complicações , Úlcera Gástrica/complicações , Úlcera Péptica Hemorrágica/induzido quimicamente , Anti-Inflamatórios não Esteroides/administração & dosagem , Artralgia/tratamento farmacológico , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Automedicação/efeitos adversos , Úlcera Péptica Hemorrágica/diagnósticoRESUMO
En el Departamento y Servicio de Cirugía del Hospital del Salvador, se ha seguido desarrollando desde el el 1 de marzo de 1989 al 1 de marzo de 1999, el programa de Cirugía Mayor Ambulatoria (CMA), habiéndose operado 1.050 pacientes, con un seguimiento a 10 años. Se destacan los beneficios integrales comprobados, además de los buenos resultados y se recomienda su implementación en todo el país