Association of insight, avoidance behavior, indecisiveness, and inflated responsibility with other clinical characteristics in children and adolescents with obsessive-compulsive disorder

Objectives: Although the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) includes ancillary symptom dimensions - insight, avoidance, degree of indecisiveness, inflated sense of responsibility, pervasive slowness/disturbance of inertia, and pathological doubting -, we know little about their clinical/scientific utility. We examined these ancillary dimensions in childhood obsessive-compulsive disorder (OCD), and tested their associations with clinical characteristics. Methods: Treatment-seeking children and adolescents (n=173) with a DSM-5 OCD diagnosis were recruited from six centers in India and evaluated with a semi-structured proforma for sociodemographic/clinical details, the Structured Clinical Interview for DSM-5, the CY-BOCS, the Children's Depression Rating Scale, and the Family Interview for Genetic Studies. Regression analysis was used to study the associations between ancillary dimensions (independent variables) and clinical variables (dependent variables). Results: 87.9% of the sample reported at least a mild-moderate severity of ancillary dimensions, which were highly intercorrelated. Multiple ancillary dimensions were correlated with illness severity on the CY-BOCS. On regression analysis, only insight and avoidance retained significance. There were few differential associations between OCD symptom and ancillary dimensions. Conclusion: Ancillary dimensions are more a feature of illness severity than differentially associated with individual symptom dimensions in childhood OCD. Insight and avoidance should be considered for inclusion in the assessment of illness severity in childhood OCD.

Escitalopram add-on in stable Schizophrenia with subsyndromal depression

Background: Significant proportion of the patients of schizophrenia suffer from subsyndromal symptomatic depressive symptoms (SSD) which not only add to the burden of disease but also to the already pre-existing challenges of living with this serious mental illness. Many psychiatrists prescribe antidepressants to patients with schizophrenia who have subsyndromal symptomatic depressive symptoms but data regarding SSD in schizophrenia is meagre. Aim was to study the effect of addition of Escitalopram on psychopathology, cognition and functioning in patients with stable schizophrenia having subsyndromal depressive symptoms and to compare these parameters with patients treated with antipsychotics alone.Methods: The study was a prospective, 8-week randomized double-blind placebo-controlled trial. Seventy four patients who fulfilled the diagnostic criteria of Schizophrenia on the basis of the ICD10-DCR, adjudged to be stable clinically and not requiring any increase in dose of antipsychotic medication over the last eight weeks were recruited into the study. The patients randomly received either Antipsychotics with add-on Escitalopram (10 mg/day) or Antipsychotics with placebo for 8 weeks. The patients were assessed using the HAM-D, CDRS, PANSS, SCoRS, SOFAS and CGI scores at the end of 8 weeks. Patients were also assessed for adverse events at baseline, week 4 and week 8.Results: A total of sixty-six patients who completed the study were analyzed. The HAM-D, CDRS and PANSS score showed significantly better cognition and functioning in the patients of add-on Escitalopram group when compared with the placebo group. There was no significant difference between the two groups in terms of observed side effects.Conclusions: Escitalopram addition to the standard anti-psychotic treatment of schizophrenia, in patients having subsyndromal depressive symptoms, results in better cognition and improved functioning.

Prescription pattern of antidepressants in five tertiary care psychiatric centres of India.

Background & objectives: Limited data are available on prescription patterns of the antidepressants from India.We studied antidepressants’ prescription pattern from five geographically distant tertiary psychiatric care centers of the India. Method: In this cross-sectional study, all patients who attended outpatients department or were admitted in the psychiatry wards at Lucknow, Chandigarh, Tiruvalla, Mumbai and Guwahati on a fixed day, who were using or had been prescribed antidepressant medications, were included. The data were collected on a unified research protocol. Results: A total of 312 patients were included. Mean age was 39±14.28 yr and 149 (47.76%) were females, 277 (87.5%) were outpatients. Among the patients receiving antidepressants, 150 (48.1%) were of diagnoses other than depression. Diabetes mellitus 18 (5.78%) was the most common co-morbid medical illness. A total of 194 (62.2%) patients were using selective serotonin reuptake inhibitors (SSRIs) with escitalopram 114 (36.53%) being the most common antidepressant used. Overall, 272 (87.18%) patients were using newer antidepressants. Thirty (9.62%) were prescribed more than one antidepressant; 159 (50.96%) patients were prescribed hypnotic or sedative medications with clonazepam being the most common (n=116; 37.18%). Interpretation & conclusions: About half of the patients with diagnoses other than depression were prescribed antidepressants. SSRIs were the most common group and escitalopram was the most common medication used. Concomitant use of two antidepressants was infrequent. Hypnotic and sedatives were frequently prescribed along with antidepressants.

Adult attention deficit/hyperactivity disorder: One year follow up.

Background & objective: This study aimed to find out phenomenology, stability of diagnosis, comorbidities, impairments and treatment status of the adults with ADHD one year follow up as there are no such data. Methods: 20 subjects (all males, mean age 25.1±6.2 yr) with adult ADHD (DSM-IV-TR) were followed up at mean 1.3±0.2 yr after their diagnosis. Phenomenological assessments were done using ASRS v1.1, WMH-CIDI, ADHD-RS and clinical assessment where required. Diagnoses of ADHD and comorbidities were made using DSM-IV-TR. Global functioning was also assessed using GAF. Results: 19 (95%) of the 20 subjects could be followed up. All (100%) of them could again be diagnosed having ADHD according to DSM-IV-TR criteria. However, the symptoms declined in severity over a period of one year. Diagnosis of 2 (10.5%) subjects of ADHD-CT was changed to ADHD-IA. 1 (5.3%) subject each of ADHD-IA and ADHD-NOS types went into partial remission. Substance abuse was increased at the follow up from 26.3 to 47.4 per cent. Rates of the other comorbidities did not change during the follow up. Only 3 (15.8%) subjects adhered to the prescribed treatment at the follow up. Global functioning of the adherent group improved significantly at the follow up (t = 6.000, P = 0.027). Interpretation & conclusion: Adult ADHD has diagnostic stability at the one year follow up. The adult ADHD subjects remained highly comorbid with other psychiatric disorders including increased substance abuse at the follow up. Only 10.5 per cent subjects remained in the regular follow up. The above findings suggest that the patients with adult ADHD should be properly psycho-educated and regularly followed up.

Stressful life event presenting as enuresis, dissociative disorder and worsening school performance.

Stressful life events are associated with various psychiatric problems. Secondary enuresis and dissociative disorders both may appear in context of traumatic life events. These problems following a trauma may further increase the risk of stress in the family and may in turn result into a vicious cycle of difficulties. We present a case report of stressful life events presenting as enuresis, dissociative disorder and worsening school performance and careful appreciation of situations and rigorous interventions improved the clinical status.