RESUMO
Three groups of rats (n = 10) were subjected to intraperitoneal treatment of formaldehyde daily at doses of 5, 10 and 15 mg/kg body weight over a period of 30 days. Gradual diminution in body and testicular weight was observed in all treated groups. Leyding cell impairement was conspicuous in those given doses of 10 and 15 mg/kg. Inhibition of 3 beta-delta 5-hydroxy steroid dehydrogenase and accumulation of sudanophillic materials in testicular tissue of formaldehyde treated rats was recorded histochemically. Significant decline of serum testosterone was also observed in the same groups. Structural and functional impairement of Leydig cells after formaldehyde treatment caused steroidogenic inhibition.
Assuntos
Animais , Peso Corporal/efeitos dos fármacos , Formaldeído/administração & dosagem , Hidroxiesteroide Desidrogenases/antagonistas & inibidores , Injeções Intraperitoneais , Células Intersticiais do Testículo/efeitos dos fármacos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Espermatogênese/efeitos dos fármacos , Testículo/efeitos dos fármacos , Testosterona/biossínteseRESUMO
The aim of this study was to assess whether 2 dimensional echocardiography can provide reliable parameters to quantitatively estimate pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease. Twenty subjects, 16 males and 4 females, mean age 54.5 year +/- 4.92 were evaluated. Right ventricular dimensions were measured using subcostal 2- dimensional (2D) approach viz. right ventricular maximum short axis (Rv) and tricuspid annulus (TA). Free right ventricular anterior wall (AW) was measured by M-Mode. A 2D Index was calculated RV x TA + Aw and the same correlated with mean pulmonary artery pressure (r = 0.97). This appears to be a useful non-invasive method foe estimating PH in cases of COPD.