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1.
Pharmaceutical Journal ; : 8-12, 2005.
Artigo em Vietnamita | WPRIM | ID: wpr-6363

RESUMO

Condensation of salicylic acid with anilines made salicylanilid derivatives. From salicylanilids, 3-phenyl-2H-1, 3-benzoxazin-2, 4(3H)-dion derivatives were created by same circle reaction. Thionylation reaction 3-phenyl-2H-1, 3-benzoxazin-2,4(3H)-dion in dioxan solvent had good result. Products of thionylation created thiosalicylanilides after circle opened hydrolysis. Clearness of thiosalicylanilides was determined by thin layer chromatography and their structure was determined by UV, IR.H1 MNR. Antibacterial effect of synthetic products, especially Streptococcus feacalis E.coli was higher than control substance as salicylanilid. Antifungal effect of Bromo and clorothiosalicylanilide derivatives was stronger than other derivatives


Assuntos
Antibacterianos , Plantas Medicinais
2.
Pharmaceutical Journal ; : 20-25, 2005.
Artigo em Vietnamita | WPRIM | ID: wpr-3701

RESUMO

Using sorbitol - a cheap and easy-to-find material in Vietnam, the authors built a relative optimal and complete protocol to synthesize isosorbide and isosorbide dinitrate (productivity of 64%). Test purity isosorbide dinitrate and solution of 25% isosorbide dinitrate. With purity isosorbite dinitrate: qualitative analysis by IR and test by HPLC method were conducted; isosorbide dinitrate solution was test according to USP 24 and checked by this standard. All products meet USP 24 standard


Assuntos
Dinitrato de Isossorbida , Sorbitol
3.
Pharmaceutical Journal ; : 15-19, 2004.
Artigo em Vietnamita | WPRIM | ID: wpr-5959

RESUMO

Study was performed on the preparation of taurine and some taurate salts in the bile of cow/ox from vissan but chery firm. Average weight of bile adder get 80 g for each. From ethamlanin and die thylcarbonate, 2- oxzolidinon was prepared, after the heating with hydrogene sulphide, taurine was obtained with a productivity of 67,15%. The investigation and extraction of taurine in laboratory scale gave a productivity of 64,5%. From taurine, calcium taurate was prepared at a productivity of 90% and magnesium taurate- 83,5%


Assuntos
Taurina , Sais , Preparações Farmacêuticas
4.
Pharmaceutical Journal ; : 21-25, 2004.
Artigo em Vietnamita | WPRIM | ID: wpr-5512

RESUMO

The synthesis of some flourosalicylanilid derivatives and the study on their antifungal activities were performed as regard the synthesis: Acid- 4 aminosalcylic was diazoidized, then reacted to NaBF4 solution- Acid 4- flourosalicyanilid was created. Acid 4- fluorosalicylic and salicylic acid were condensed to aniline derivatives for creating 9 derivatives of fluorosalicylic. The synthetized substances were purified, fusion point and thin layer chronatography were determined. In products antibacterial inanifested and antifungal were in experimental concentration. Relatively strong activity of 3'- flourosalicyanilid had exerted on S. aureus; MRSA at the concentration of 9 microgram/ml and 18 microgram/ml; and 3'- flourosalicyanilid, 4'- flourosalicyanilid reacted relatively strongly on Microsporum nanum, Trichophyton mentagrophyle. Microsporum gypseum at the concentration of 2 microgram/ml and microgram/ml


Assuntos
Preparações Farmacêuticas , Antifúngicos , Antibacterianos
5.
Pharmaceutical Journal ; : 11-13, 2004.
Artigo em Vietnamita | WPRIM | ID: wpr-5372

RESUMO

From the cow's bile, which is by product of food manufacture installations in Ho Chi Minh city, was surveyed and built up a progress for isolating cholic acide. From cholic acide by five steps obtained chenodeoxycholic acide. The product come up to the standard of BP 2000


Assuntos
Ácido Cólico , Experimentação Animal , Ácido Quenodesoxicólico
6.
Pharmaceutical Journal ; : 17-20, 2003.
Artigo em Vietnamita | WPRIM | ID: wpr-5882

RESUMO

The report suggested that the ways to synthesize substances belong to 4-bromothioure derivatives. By reaction between 4-broucroanilin and CS2 in amoniac environment, collected 4 bromophenyl dithiocarbamat. This substance react with nitrate lead and collected 4 flurothiocyanate, and then can synthesize above substance. Synthesized substances were measured pure level, defined it's physico-chemical constants as well as structure. For antibacterial and anti-fungus, the trial will have result when 3 microfungal strains and 3 bacterial strains contact with 4-bromothioure derivative


Assuntos
Antibacterianos , Antifúngicos , Preparações Farmacêuticas
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