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Chinese Journal of Hematology ; (12): 736-739, 2004.
Artigo em Chinês | WPRIM | ID: wpr-229907

RESUMO

<p><b>OBJECTIVE</b>To compare the expression profiles of a set of homing-related molecules (HRM) repertoire expressed on hematopoietic stem/progenitor cells (HS/PC) from different sources.</p><p><b>METHOD</b>The expression levels of HRM on HS/PC from umbilical cord blood (UCB), mobilized peripheral blood (mPB) and bone marrow (BM) were assessed using a highly sensitive 4-color flow cytometric analysis.</p><p><b>RESULTS</b>UCB-derived CD34(bright) cells, as well as mPB- and BM-derived CD34(bright) cells strongly expressed CD44, CD11a, CD18, CD62L, CD31 and CD49d. On the other hand, significantly lower expressions of CD49e, CD49f, CXCR-4 and CD54 on UCB-derived CD34(bright) and CD34(bright)CD38(-) cells, compared with those on mPB- and BM-derived CD34(bright) and CD34(bright)CD38(-) cells, were observed. None of UCB-, mPB- and BM-derived CD34(bright) cells expressed other chemokine receptors, including CCR-1, CCR-2, CCR-3, CCR-5, CXCR-1, CXCR-2, CXCR-3 and CXCR-5. Another striking finding was that only mPB-derived CD34(bright) cells expressed significant levels of both the matrix metalloproteinases MMP-2 \[(11.4 +/- 4.9)%\] and MMP-9 \[(27.6 +/- 7.8)%\].</p><p><b>CONCLUSION</b>HS/PC from UCB have some defects of expression of HRM repertoire, which might partly explain the cause(s) of delayed hematopoietic reconstitution after UCB transplant.</p>


Assuntos
Humanos , Recém-Nascido , Antígenos CD34 , Alergia e Imunologia , Células da Medula Óssea , Biologia Celular , Alergia e Imunologia , Metabolismo , Antígeno CD11a , Alergia e Imunologia , Antígenos CD18 , Alergia e Imunologia , Moléculas de Adesão Celular , Metabolismo , Células Cultivadas , Sangue Fetal , Biologia Celular , Citometria de Fluxo , Mobilização de Células-Tronco Hematopoéticas , Células-Tronco Hematopoéticas , Biologia Celular , Alergia e Imunologia , Metabolismo , Receptores de Hialuronatos , Alergia e Imunologia , Metaloproteinases da Matriz Secretadas , Metabolismo , Molécula-1 de Adesão Celular Endotelial a Plaquetas , Alergia e Imunologia , Receptores CXCR4 , Metabolismo
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