RESUMO
Background: Differences in pulmonary function are influenced by ethnic, genetic or environmental factors pollution, nutritional status and exercise. Appropriate reference values are needed for the assessment o fpulmonary disease.No published studies regarding spirometric values of healthy children and adolescents of the northeast of Thailand have been reported.Objectives: To determine predictive equations for forced expiratory volume in one second (FEV), forced vital capacity (FVC) and dthe fodrced expiratory flow (FEF), and evaluate whether they are different from other ethnic groups.Methods: Standard spirometry was performed in 470 healthy children and adolescents of Kaennakorn wittayalai school (305 males) 12 to 19 years of age using the Eagle one spirometer. Regressopm analyses using height (H) and age (A) as independent variables were applied for both sexs.Results: Almost all-spirometric volumes were systematically lower than those of Europe, Polynesian, and Chinese. Predictive equations were; In male: FVC = 0.054H+0.062A-6.596 (r = 0.863), FEV = 0.046H+0.073A-5.779 (r = 0.862) FEF = 0.062H+0.173A-6.9.9 (r = 0.552), FEF = 0.048H+0.165A-5.968 (r = 0.566), FEF = 0.03H+0.131A-4.478 (r = 0.555), FRF = 0.0455H+0.145A-5.655 (r = 0.592) PEF = 0.075H+0.146-8.127 (r = 0.510), FEV = 0.029H+0.16-2.615 (r = 0.500), FEF =-0.073H-0.07A+17.339 (r = 0.280), FEF = -0.081H-0.045A+17.703 ( r = 0.418), FEF = -0.035H+0.173A+5.391 (r = 0.552), FEF = -0.055H+0.06A+0.06A+11.5 (r =0.350), PEF = -0.071H-0.097A+17.768 (r = 0.231).Conclusions: This study confirms the previous studies by others that apart from the FEF FVC and its componendts were systematically lower than those of Caucacians. Further studies in a larger number of population are needed before establishing “normal” values for the northeast Thai children and adolescens,
RESUMO
Background: Diabetes is a condition which is known to be associated with a variety of connective tissue abnormalities which contribute to impaired wound healing, leading to the chronic ulcer formation. Centella asiatica Linn. and Garcinia mangostana Linn. are widely used as Thai traditional medicine including wound treatment. However, the effects of both plant extracts in diabetic condition had not been experimented.Objective: To study the effects of topical administration of Centella asiatica Linn. and Garcinia mangostana Linn. on diabetic wound.Materials and Methods: Male Spraque-Dawley rats (64 rats) were divided into 2 groups: Normal control and diabetes induced groups, each group was divided into 4 groups. The wounds were and treated by placebo, Centella asiatica Linn., Garcinia mangostana Linn. and neomycin.Results: It was shown that the wounds of the treated group epithelialized faster and the wound contraction rate was higher than the non-treated groups.Conclusion: The present study results confirmed the folkloric utilization and suggested the beneficial effects of both plant extracts for treating diabetic wounds in human being. However, the further studies with purified constituents were required to understand the complete mechanism of wound healing promotion induced by both Centella asiatica Linn. and Garcinia mangostana Linn.Key words: wound healing, diabetes, Centella asiatica Linn., Garcinia mangostana Linn.