Comparison of the curative effect and safety of rifapentine and rifampicin in smear positive pulmonary tuberculosis patients / 中国生化药物杂志

Objective To compare the clinical therapeutic effect and safety of rifapentine and rifampicin in smear positive pulmonary tuberculosis patients.Methods A total of 80 patients with smear positive pulmonary tuberculosis were chosen in Changshan People's Hospital from June 2015 to July 2016,the patients were randomly divided into control group(n=40)and observation group(n=40).The control group used rifampicin treatment,observation group were treated with rifapentine therapy,the therapeutic effect and incidence of complications between two groups were compared.Results Proportion of the sputum smear negative,cavity closure and lesions absorption in the observation group after 6 months of treatment were significantly higher than those in the control group; peripheral blood T lymphocyte subsets CD3+,CD4+,CD8+ levels in two groups before treatment had no statistically significant differences; peripheral blood of T lymphocyte subsets CD3+,CD4+,CD8+ levels in the observation group after treatment were significantly higher than those in the control group(P<0.05); incidence of complications in observation group(7.5％)after treatment was significantly lower than that in the control group(17.5％)(P<0.05).Conclusion Compared with rifampicin in treatment of smear positive pulmonary tuberculosis patients,rifapentine has ideal treatment effect,can improve the immune function,low incidence of complications.

Clinical effect of shenlingbaizhu powder combined with flupentixol and melitracen tablets in treatment of spleen deficiency and liver stagnation type IBS-D / 中国生化药物杂志

Objective To investigate clinical effect of shenlingbaizhu powder combined with flupentixol and melitracen tablets in treatment of spleen deficiency and liver stagnation type IBS-D.Methods 70 cases of liver depression and spleen deficiency type diarrhea predominant IBS patients were selected and in accordance with the principle of random number were divided into observation group and control group, 35 cases in each group, control group was treated with shenlingbaizhupowder treatment, observation group was given shenlingbaizhu powder combined with flupentixol and melitracen tablets treatment,clinical curative effect between two groups was compared.Results The effective rate of the observation group was 91.43%, was higher than that of control group 77.14% (P<0.05).After treatment, the SDS score and SAS score of the two groups were improved (P<0.05), and the improvement effect of observation group was more obvious ( P <0.05 ) .Conclusion Shenlingbaizhu powder combined with flupentixol and melitracen tablets has good effect in treatment of liver depression and spleen deficiency type IBS-D, it is worthy of clinical application.