In-vitro antioxidant and anti-hyperlipidemic activities of Blumea eriantha DC

Alcoholic and water extracts of the stem and root of Blumea eriantha DC were prepared and evaluated for in-vitro antioxidant activity by methods like total reducing power, scavenging of us free radicals like as 1,2-diphenyl-2-picrylhydrazyl [DPPH], super oxide, nitric oxide, and hydrogen peroxide. The percentage scavenging effect of free radicals was compared with standard antioxidants like ascorbic acid and Butylated-hydroxyl anisole [BHA]. Different extracts were also tested for anti-hyperlipidemic activity in triton WR-1339 [iso-octyl polyoxyethylene phenol]-induced hyperlipidemia in albino rats by determination of serum triglyceride like VLDL, LDL, HDL levels. Significant antioxidant activity was estimated in different methods, [P<0.01] for reducing power and [P<0.001] for scavenging DPPH, super oxide, nitric oxide, and hydrogen peroxide radicals. The different extracts having significant reduction [P<0.01] in cholesterol at 6 and 24 h and [P<0.05] at 48 h. There was significant reduction [P<0.01] in triglyceride level at 6, 24 and 48 h. There was significant increase [P<0.01] in HDL at 6, 24 and 48 h. From the VLDL was also significantly [P<0.05] reduced from 24 h and maximum reduction [P<0.01] results, it is clear that alcoholic and water extracts of Blumea eriantha DC can remarkably decrease plasma cholesterol, triglyceride, LDL, and VLDL and increase plasma HDL levels. In addition, the alcoholic and aqueous extracts have shown significant antioxidant activity

Synthesis, characterization and biological activity of some 1, 3, 4-thiadiazol derivatives

Thiadiazoles are their derivatives exhibit a wide variety of pharmacological activities such as Antibacterial and anti-inflammatory. In the present study we have synthesized derivatives some 2,5 substituted 1,3,4-thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR, and MASS spectra data. These compounds were evaluated for varies biological activities such as antibacterial and anti-inflammatory activity