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Asian Pacific Journal of Tropical Biomedicine ; (12): 232-236, 2013.
Artigo em Inglês | WPRIM | ID: wpr-312421

RESUMO

Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.


Assuntos
Animais , Humanos , Dengue , Terapêutica , Vírus da Dengue , Genética , Interferência de RNA , RNA Interferente Pequeno , Genética , Usos Terapêuticos
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