A Pilot Study to Evaluate the Effects of Cerebroprotein Hydrolysate on Neurological Outcomes and Hospital Stay in Patients Admitted for Ischemic and Hemorrhagic Stroke

Introduction: Neurological stroke is the most common cause of disability and leaves nearly 65% of survivors with sensory, motor and coordinative disabilities. At present, there are no therapies to prevent long-term neurological deficits after stroke. Many neuroprotective drugs are being tested with the aim to ensure these effects. Preclinical studies have shown a modulatory effect of cerebroprotein hydrolysate on synaptic remodeling and facilitated synaptic transmission. Material and methods: This was a hospital-based, open-label pilot study conducted in a tertiary care hospital of North India. All patients admitted with a diagnosis of stroke both ischemic and hemorrhagic, were included in the study. Patients were randomized into two groups. The test group was given cerebroprotein hydrolysate, along with standard treatment for stroke, whereas the other group was kept on standard treatment for stroke as per the latest guidelines, without cerebroprotein. Results: A total of 50 patients of stroke, admitted in a tertiary care center were included in the study. The mean age of the patients was 65.7 ± 11.86 years. Twenty-six (52%) were males and 24 (48%) were females. Out of the total 50 patients, 23 (46%) had ischemic stroke and 27 (54%) had hemorrhagic stroke. Twenty (40%) had diabetes, 37 (74%) had hypertension, 8 (16%) were known cases of coronary artery disease, 28 (56%) had dyslipidemia, 22 (44%) were smokers, 7 (14%) had a history of ethanol consumption and 13 (26%) were obese. Mean Barthel score at admission was 21.2 ± 11.3 and mean Rankin score at admission was 3.6 ± 1.37. Mean Barthel score at end of treatment was 53.9 ± 28.72 and mean Rankin score at end of treatment was 2.6 ± 1.65. The mean duration of admission was 6.8 ± 3.57 days. Conclusion: The current study highlights the role of cerebroprotein hydrolysate in improving the neurological scores and reducing hospital stay among patients hospitalized with stroke.

A Pilot Study to Evaluate the Effects of Cerebroprotein Hydrolysate on Neurological Outcomes and Hospital Stay in Patients Admitted for Ischemic and Hemorrhagic Stroke

Introduction: Neurological stroke is the most common cause of disability and leaves nearly 65% of survivors with sensory, motor and coordinative disabilities. At present, there are no therapies to prevent long-term neurological deficits after stroke. Many neuroprotective drugs are being tested with the aim to ensure these effects. Preclinical studies have shown a modulatory effect of cerebroprotein hydrolysate on synaptic remodeling and facilitated synaptic transmission. Material and methods: This was a hospital-based, open-label pilot study conducted in a tertiary care hospital of North India. All patients admitted with a diagnosis of stroke both ischemic and hemorrhagic, were included in the study. Patients were randomized into two groups. The test group was given cerebroprotein hydrolysate, along with standard treatment for stroke, whereas the other group was kept on standard treatment for stroke as per the latest guidelines, without cerebroprotein. Results: A total of 50 patients of stroke, admitted in a tertiary care center were included in the study. The mean age of the patients was 65.7 ± 11.86 years. Twenty-six (52%) were males and 24 (48%) were females. Out of the total 50 patients, 23 (46%) had ischemic stroke and 27 (54%) had hemorrhagic stroke. Twenty (40%) had diabetes, 37 (74%) had hypertension, 8 (16%) were known cases of coronary artery disease, 28 (56%) had dyslipidemia, 22 (44%) were smokers, 7 (14%) had a history of ethanol consumption and 13 (26%) were obese. Mean Barthel score at admission was 21.2 ± 11.3 and mean Rankin score at admission was 3.6 ± 1.37. Mean Barthel score at end of treatment was 53.9 ± 28.72 and mean Rankin score at end of treatment was 2.6 ± 1.65. The mean duration of admission was 6.8 ± 3.57 days. Conclusion: The current study highlights the role of cerebroprotein hydrolysate in improving the neurological scores and reducing hospital stay among patients hospitalized with stroke.

Relationship of qSOFA values to gastric perforation patients in A. W. Sjahranie General Hospital, Samarinda, Indonesia

Background: Authors hypothesized the qSOFA score would be useful in sepsis patients caused by gastric perforation. The present study investigated the relationship of qSOFA value to outcome of patients with gastric perforation in Samarinda.Methods: This research was analytical, descriptive research method using cross-sectional study design 70 patients. Data analysis was obtained to see the relationship between age, gender, vital sign qSOFA and survival in gastric perforation patients.Results: Mean systolic blood pressure was significantly higher in subjects who lived than those who died, i.e. 105.5 vs 92.5 (p <0.001). Mean diastolic blood pressure was significantly higher in subjects who lived than those who died, ie 80.0 vs 66.8 (p <0.001). The respiration rate was significantly lower in subjects who lived than those who died, namely 22.9 vs 24.6 (p <0.001). The mean GCS score was significantly higher in subjects who lived than those who died, ie 14.2 vs 12.2 (p <0.001).Conclusions: The higher the qSOFA score in the study subjects with gastric perforation, the higher the mortality rate. There was a relationship between the qSOFA value and the outcome of patients with gastric perforation where the mean qSOFA score was significantly lower in subjects who lived than those who died.

Myocardial Performance Index in Patients of Acute Coronary Syndrome.

Evaluation of ventricular systolic and diastolic functions is an essential part of echocardiographic evaluation in a patient of acute coronary syndrome (ACS). Both systolic and diastolic functions change as disease progresses. There are many limitations of the echocardiographic indices of LV functions used routinely in patients of acute coronary syndrome. Tei Chuwa devised a reliable index of myocardial performance (The Tei Index/ Myocardial Perfomance Index). It is a reliable index for evaluation of LV systolic and diastolic performance in acute coronary syndrome. Materials and Methods: 75 patients of acute coronary syndrome and 25 controls were studied. All patients admitted with the complaints of ischemic chest pain were included in the study. An informed consent was taken from all patients. Detailed history and physical examination were carried out and baseline investigations were done. Tei index was calculated from the ratio of time intervals: a-b/b, derived with the aid of pulse doppler echocardiography. Its relationship was studied with acute coronary syndrome and complications after ACS. Results: The Cardiac Output was not significantly different from controls in UA; but it was significantly deranged in STEMI (p<0.001) and NSTEMI (p <0.001). MPI was significantly different in all the three groups from controls. The t and p values of MPI of various groups on comparison with controls were t=9.0, p<0.001; t=12.5, p<0.001; t=18, p< 0.001 for UA, STEMI and NSTEMI respectively. The MPI of STEMI patients was 0.64±0.08 that of NSTEMI patients was 0.57±0.059, that of UA was 0.48±0.06 and that of controls was 0.39±0.04. The correlation showed that MPI was more strongly related to complications as compared to other echocardiographic parameters. Conclusion: MPI is a non-geometric doppler index, that combines systolic and diastolic performance of left ventricle. As compared to controls, MPI was found to be deranged in patients of acute coronary syndrome. when recorded within 24 hours of admission, myocardial performance index was a sensitive and independent predictor of in-hospital events.

A Study on Ventricular Late Potentials by Signal Averaged Electrocardiogram in Myocardial Infarction Patients.

Fifty patients who presented with Myocardial Infarction (MI), diagnosed by history, ECG, enzymes were subjected to late potential analysis between 7-10 days post MI by Signal Averaged Electrocardiography (SAECG). There were 42 male and 8 female patients. 34 had anterior wall MI and 16 had inferior wall MI, and all of them had Q wave infarction. History of previous MI in 12, diabetes in 14, hypertension in 34, smoking in 24 and hypercholesterolemia in 8 was noted. Patients were followed up for one year. Late potentials were positive in 10 patients (62.5%) of inferior wall MI and 6 patients (17.5%) of anterior wall MI. Those with episodes of ventricular tachycardia had increased incidence of late potentials. There was no correlation of late potentials and LV function assessed by echocardiography. Thrombolysed group had decreased incidence of late potentials.

Relationship between qooba [dermatophytosis] and mizaj temperament

In this study we have tried to assess the Mizaj [temperament] of the patients of Qooba [dermatophytosis]. Among 126 patients we have found that maximum number of patients [46.83%] belonged to Saudawi temperament, followed by Damwi [31.75%], Balghami [24.60%] and Safrawi [13%] temperament

Awake rigid bronchoscopy for post intubation tracheal stenosis

Prolonged tracheal intubation is a common cause of tracheal stenosis. These patients may present with respiratory insufficiency and stridor of insidious onset and progressive nature. Immediate management includes securing the airway which requires anesthesia. We present successful management of a case of post intubation tracheal stenosis using rigid bronchoscopy under a combination of regional and general anesthesia