[Incidence rate of acute reactions in transfusion of blood and its products prepared by Urumia Blood Refinery Center]

"Blood transfusion is one of essential and important but dangerous parts of today's medicine in which if appropriate measures have not been done, fatal reactions may occur. Acute hemolytic reactions, febrile reactions, and allergic reactions are among the most important and most prevalent transfusion reactions that happen shortly after its beginning and can lead to considerable mortality and morbidity. The aim of this descriptive study was to investigate the prevalence of acute reactions of blood and its products prepared by Urumia Blood Refinery Center. 3880 blood product units transfused to 1261 patients were studied by convenience sampling method. Various instruments and methods such as sphygmomanometer, thermometer, urine analysis, interview and observation were used for data gathering. Collected data were documented in special forms designed for this purpose. Descriptive statistics were used for data analysis. Among the blood recipients, 604 were female and 657 were male. The most frequent complaints of patients were coldness [22.5%], pruritus [20.1%] and chills [18.1%]. The prevalence of acute hemolytic reaction, febrile reaction and allergic reactions were 0.52, 6.2 and 11.1 per 1000 transfusions respectively. In spite of improved blood refinement techniques, acute transfusion reactions can lead to significant morbidity and mortality. Therefore, physicians', nurses' and midwives' meticulous attention to early symptoms and signs of acute reactions to transfusion of blood and its products have an important role in preventing adverse outcomes of this life-saving remedy

[Effect of lactobacillus acidophilus on adults habitual constipation in gastrointestinal clinic of Ghaem Hospital in Mashhad: a pilot study]

Constipation is a common problem in elderly subjects. Probiotics have been suggested to improve intestinal motility and to reduce fecal enzyme activity. In this study, the effect of lactobacillus acidophilus tablets on elderly subjects was compared with placebo. Elderly subjects [n = 48] with chief complaint of constipation were enrolled in a randomly double-blind study. The subjects were divided into 2 groups: control group, receiving placebo every 8 hours for one month, and study group, receiving lactobacillus acidophilus tablet every 8 hours for one month. Subjects with lactose intolerance and other pathologic conditions were omitted. At the end of 4 weeks, all subjects were questioned on the relief of constipation and other symptoms. Response to treatment and complications were compared between the two groups. In subjects receiving lactobacillus acidophilus, 50%[13 subjects] responded well and had relief of constipation, 23.1%[6 subjects] showed relative response and 26.9%[7 subjects] did not respond. In subjects receiving placebo, 40% [6 subjects] had relief of constipation, 13.3% [2 subjects] responded relatively well and in 46.7% [7 subjects] no response was seen [p=0.388]. New signs were observed in 5 subjects [19.2%] receiving lactobacillus acidophilus and 1 subject [6.7%] receiving placebo. After 4 weeks, 2 subjects [7.7%] receiving lactobacillus acidophilus and 1 subject [6.7%] receiving placebo re-experienced constipation. Some relief of constipation could be observed with lactobacillus acidophilus tablets, but there was no significant difference between the two groups