RESUMO
Background: The corona virus disease (Covid-19) is a pandemic which is rapidly evolving and expanding, has infected a population of more than 77 million across the globe and around 10 million in India as of 25th December 2020. This virus was first recognized in December 2019 in Wuhan of China when pneumonia of unknown origin came into limelight. It was identified as Covid -19, a neo virus causing severe pneumonia that rapidly led to a major health crisis with devastating consequences not only in India but also in major developed countries of the world. Initially data from China and Italy, which was identified as caused by Covid-19, shows that death rate worsens in persons with increasing age more than 50 years and also leads to higher risk due to co-morbidities like hypertension (HTN), cardiac disease, diabetes mellitus, chronic renal disease, cancer, etc. Severe acute respiratory viral infections are frequently accompanied by multiple organ dysfunction, including acute kidney injury (AKI). While diffuse alveolar damage and acute respiratory failure are the main features of Covid-19, and the incidence of AKI is not well described. The present study was conducted to assess the Renal Involvement and its association with Prognosis among Patients admitted with Covid- 19 Pneumonia. Aim: To assess the renal involvement and its association with prognosis among patients admitted withCovid-19pneumonia. Materials and methods: A single centered cross-sectional study was conducted at Malla Reddy Institute of Medical Sciences during 15th March to 1stMay 2021 where 151 Patients admitted with Covid-19 Positive on RT-PCR were included. Renal function tests include Creatinine and Urea. The most commonly used endogenous marker for the assessment of glomerular function is creatinine. The calculated clearance of creatinine is used to provide an indicator of GFR. Urea is a nitrogen- containing compound formed in the liver as the end product of protein metabolism and the urea cycle. Serum urea levels increase in conditions where renal clearance decreases (in acute and chronic renal failure/ impairment). Urea may also increase in other conditions not related to renal diseases such as upper GI bleeding, dehydration, catabolic states, and high protein diets. Data entry was done using Excel 2013 and analysis using SPSS v16. Student t test and chi-square test were used to find the significant association without come. Results: A total of 151 patients who had tested positive for COVID-19 were included in the study. The mean age in years of the study participants was 47.76�.85. 72.8% were male and 27.2% were female. The mean serum creatinine was 1.44�94 and mean Blood urea was 41.35�.06. Mortality observed in the study was 44.4%. Significantly high levels of serum creatinine (2.06�10) were reported among those who died due to COVID-19 compared to those who recovered (0.93�28) (p<0.0001) in the study. Our study poses a conclusion of increase in serum creatinine in COVID 19 affected patients that shows a temporal association of SARsCOV�with AKI. Conclusion: The Covid pandemic has posed major challenge around the globe. Renal clinical presentation ranging from mild proteinuria, hematuria to progressive AKI necessitating renal replacement therapy (RRT), thrombotic microangiopathy and rhabdomyolysis. More research is needed to obtain adequate evidence to support current clinical approaches and to develop new approaches to management. Kidney failure occurs in most patients with COVID-19 pneumonia. Although proteinuria, hematuria and AKI are usually resolved in such patients within 3 weeks after the onset of symptoms, kidney problems in COVID-19 have been associated with higher mortality. AKI is independent predictor of mortality in Covid-19