RESUMO
A 45-year-old male presented with dysphagia, anorexia and progressive weight loss. He was a chronic smoker. Oesophagoscopy showed an ulceroproliferative growth of 25-30 cm size. Histopathology from the biopsy tissue showed small cell (oat cell) carcinoma. He received radiotherapy, but died 9 months later. Small cell carcinoma of the oesophagus constitutes 0.8-2.4% of all the oesophageal carcinoma. The tumour is an aggressive one with a poor prognosis irrespective of the treatment.
Assuntos
Carcinoma de Células Pequenas/diagnóstico , Neoplasias Esofágicas/diagnóstico , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Amyloidosis of the gastrointestinal tract is often asymptomatic. We report a 65-year-old man who presented with anorexia, dyspepsia and vomiting. Endoscopy showed nodular duodenal mucosa, which on histology showed amyloidosis. The patient died two weeks later.
Assuntos
Idoso , Amiloidose/diagnóstico , Duodenopatias/diagnóstico , Humanos , MasculinoRESUMO
Gastric xanthelasma, a benign condition, has been reported before; there has been no documentation of xanthelasma of the esophagus. We report a patient with xanthelasma of the stomach and esophagus.
Assuntos
Adulto , Doenças do Esôfago/complicações , Esofagoscopia , Feminino , Mucosa Gástrica/patologia , Gastroscopia , Histiócitos/patologia , Humanos , Prognóstico , Gastropatias/complicações , Xantomatose/complicaçõesRESUMO
Methanolic extracts of the flowers of M. champaca, I. Brachiata and R. cana were found to possess antiinflammatory activity against cotton pellet granuloma in rats at a dose level of 100 mg/kg body weight, sc. The latter two drugs showed higher activity (AIA) as compared to that of M. champaca. They reduced the protein content, acid phosphatase, glutamate pyruvate transaminase and glutamate oxalo-acetate transaminase activities in liver and serum. A significant reduction in the ascorbic acid content in adrenals was also observed in drug-treated animals. R. cana was recorded to possess significant antipyretic activity from the first hour of administration. These pharmacological properties may be traced to the presence of flavonoids in the flowers of these plants.
Assuntos
Analgésicos não Narcóticos/uso terapêutico , Animais , Anti-Inflamatórios/uso terapêutico , Flavonoides/isolamento & purificação , Granuloma/tratamento farmacológico , Índia , Extratos Vegetais/uso terapêutico , Plantas Medicinais/química , RatosRESUMO
In Physarum polycephalum, transcription is significantly inhibited for the whole of the ultra violet-induced, extended G2 phase. Although, there is some increase in the rate of transcription closer to the first post-irradiation mitosis, thereafter, ovrall synthesis continues to be low. Also, the plasmodia developed significant resistance to actinomycin D during this period. The resistance is both in terms of mitosis and RNA synthesis. The overall depression in transcription and the drug resistance are apparently related phenomena.