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Journal of Infection and Public Health. 2008; 1 (2): 105-112
em Inglês | IMEMR | ID: emr-87893

RESUMO

The increase of multi-drug resistant Pseudomonas aeruginosa infections is a worldwide dilemma. At the heart of the problem is the inability to treat established P. aeruginosa biofilms with standard antibiotic therapy, including fluoroquinolones. We address a previously unstudied question as to the effect of a commonly prescribed calcium channel blocker [CCB] diltiazem on the biofilm growth. Real-time monitoring of the overall growth and killing of P. aeruginosa biofilm during fluoroquinolones therapy in the presence and absence of diltiazem was performed. In this study, we demonstrate that for P. aeruginosa biofilms, resistance to the first-line fluoroquinolones may be induced by the commonly prescribed calcium channel blocker diltiazem


Assuntos
Farmacorresistência Bacteriana , Fluoroquinolonas , Diltiazem/efeitos adversos , Interações Medicamentosas , Biofilmes , Infecções por Pseudomonas/tratamento farmacológico , Resistência a Múltiplos Medicamentos
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