RESUMO
Verapamil in minimum therapeutic equivalent dose, failed to show anti-inflammatory activity as did sub-anti-inflammatory dose of aspirin (54 mg/kg) however, when combined with sub-antiinflammatory dose of aspirin, significant (P < 0.001) inhibition of carrageenan and cotton pellet induced inflammation was observed. The anti-inflammatory activity of this combination treatment was almost comparable to that of the anti-inflammatory dose of aspirin (200 mg/kg), as confirmed by granuloma histology. Adrenal weight in the combination treatment group was similar to that of aspirin (200 mg) treated group and was significantly lower, as compared to controls. Further, a reduced ulcer index in the animals treated with combination (aspirin + verapamil), as compared to aspirin alone (200 mg) group, suggests its therapeutic potential.