RESUMO
Carcinoma of the esophagus can metastasize to unusual sites. We report a patient with esophageal carcinoma with retrograde spread to the mesenteric and iliac lymph nodes from celiac nodes, demonstrated by magnetic resonance imaging and confirmed by FNAC.
Assuntos
Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Neoplasias Esofágicas/diagnóstico , Feminino , Humanos , Ílio , Metástase Linfática , Imageamento por Ressonância Magnética , Mesentério , Pessoa de Meia-IdadeRESUMO
Hexachlorocyclohexane (HCH) at different concentrations (0.5 to 5.0 ng/ml) mixed with food was fed to third instar larvae of hsp26-lacZ transgenic Drosophila for 2 hr and hsp26 gene expression was examined by beta-galactosidase staining. Puffing in salivary gland polytene chromosomes was also studied. Brain and midgut of larvae showed dark blue staining at 2.0 and 5.0 ng/ml of HCH. Absence of induced puffing at 67B and 84D in the salivary gland polytene chromosomes indicated that these glands are not affected. The study suggests presence of the vulnerable sites in larvae to the higher concentrations of HCH.
Assuntos
Animais , Animais Geneticamente Modificados , Proteínas de Drosophila , Regulação da Expressão Gênica/efeitos dos fármacos , Proteínas de Choque Térmico/genética , Hexaclorocicloexano/farmacologiaRESUMO
Changes in lipid peroxidation and superoxide dismutase level in rat brain due to single exposure to diethyl ether (anaesthetic) were studied in 100 and 300 day old rats. Enhancement of superoxide dismutase activity was more pronounced in young rat brain, while the reverse was the case with lipid peroxidation. The neurotoxic effects of diethyl ether may involve active oxygen species and superoxide dismutase activity increases as a defensive adaptation.