RESUMO
Background: Diastolic heart failure occurs due to impaired myocardial relaxation and compliance. Of late, it has been suggested that the changes in the diastolic function occurs before the onset of diabetes, and present in the prediabetic patients. It is also said to be associated with insulin resistance.Methods: This observational study was performed on 50 diabetic patients, with asymptomatic type 2 diabetes. who came in for 2 D echocardiogram with suspected diastolic dysfunction.Results: The mean age among the 50 patients in the study was 54.1±10.99 years and in controls it was 49.56±10.63 years. The fasting sugar among the patients was 179.43±41.57 mg/dl and the post prandial was 236.72±76.24, and it was in the normal range in the controls. The HbA1c was 9.93±1.2 among the patients and 6.09 ± 0.34 in the controls. In the patients, the E/A ratio was 0.83±0.09 compared to 1.22±0.31 of the controls, which was highly significant as the E/e ratio which was 15.1±3.4 and 7.3±0.08 respectively.Conclusions: There was a higher prevalence of diastolic dysfunction among the patients with diabetes in our study. There was no relation of age or gender among the diabetic and the controls, while a strong association and indicators seem to be FBS, PLBS and HbA1c.
RESUMO
Background: Polycystic ovarian syndrome reported to be one of the most common endocrine disorders in the women of the reproductive age, causing oligoovulatory infertility. In many cases, apparently healthy looking women are being diagnosed with either subclinical or overt hypothyroidism after having the symptoms of PCOS. This study was done to analyse the association of PCOS and hypothyroidism in our geographical area.Methods: 50 women of reproductive ages between 18 to 45 years, who were diagnosed with PCOS, based on Rotterdam’s criteria, 2003 and 50 healthy women as controls, were included into the study. After taking the demographic details from all the patients, they were all subjected to ultrasound for the detection of the cysts. Blood was collected for various biochemical tests including the thyroid profile. Results: The mean age of all the patients in the study group was 23.6±7.2 compared to 27.1±4.6 of the healthy controls. The Body Mass Index amongst both the groups was 29.1±3.1 and 23.4±2.9 kg/m2 respectively. The levels of thyroid profile were significantly high among the study group with 58%, 54%, 68% as the number of patients with elevated T3, T4 and TSH values. The prevalence of subclinical hypothyroidism was 48.3%, while 51.7% of them had overt hypothyroidism. A higher BMI was found among the patients with PCOS and hypothyroidism.Conclusion: The prevalence of hypothyroidism among the PCOS patients is certainly on the rise accentuating its association with this endocrine disorder especially among the young adults.