Diagnostic dilemma of primary mucosal leishmaniasis

Leishmaniasis is caused by Leishmania protozoa. It is widely present in more than 88 countries worldwide, resulting in up to 80, 000 deaths annually. Leishmaniasis occurs as visceral, cutaneous, or mucocutaneous variants. Mucosal involvement can occur secondarily to the cutaneous or visceral varieties. However, primary mucosal leishmaniasis [PML] occurs without any present or past cutaneous and or visceral disease. It is extremely rare, and its diagnosis may present a serious challenge. It may be difficult to differentiate it from granulomatous conditions like tuberculosis, sarcoidosis, leprosy, fungal infections, Wegener's granuloma, and neoplasms. Here, we present a case of PML in Saudi Arabia

Potential antithyroid agents: V Synthetic and pharmacological studies on some N-arylN- benzoythiocarbamides

THE ANTITHYROID agents are of great therapeutic interest as they offer a method for correcting a hyperfunctioning gland without resort to surgery. They lower the metabolic rate by interfering with the synthesis, release or peripheral action of the thyroid hormone. The highly active antithyroid substances contain thiourea moieties, NHCSNH, capable of being easily oxidized. The suggestion has been made that the interference with thyroxine synthesis is by a direct reaction between I[2] and SH [formed by enolization] to form a disulphide [1-4]. The present communication deals with the synthesis and pharmacological studies of some N-aryl-N[']-benzoylthiocarbamides. The interest in the synthesis and pharmacological studies of these compounds as antithyroid drugs is due to the fact that acylisothiocyanates possess enhanced reactivity on account 0f the electron withdrawing acyl groups attached to the thioureidolinkage and the acylisothiocyanates on reaction with amino compounds usually give acylderivatives of thiocarbamides. The synthesis has been affected by the condensation of benzoylisothiocyanate [I] with different amines [II]