Expression of miR-21, miR-221, and miR-222 in exosomes of CAL27 tongue squamous cell carcinoma cells / 口腔疾病防治

Objective@# To assess the expression of miR-21, miR-221, and miR-222 in exosomes of CAL27 tongue squamous cell carcinoma cells.@*Methods @# CAL27 tongue squamous cell carcinoma cells and normal human oral keratinocytes (HOKs) were cultured, and then, the cultured supernatant was collected to separate the exosomes. Exosomes were detected by electron microscopy, and the expression levels of miR-21, miR-221, and miR-222 in the exosomes of tongue cancer cells were measured by qRT-PCR. @*Results@#Exosomes existed in the cultured supernatants of CAL27 cells and HOKs. Additionally, the expression levels of miR-21, miR-221, and miR-222 in the exosomes of CAL27 cells were significantly enhanced compared with those in the HOK exosomes (P < 0.05). @*Conclusion @#The expression levels of miR-21, miR-221, and miR-222 were markedly enhanced in the exosomes of CAL27 tongue squamous cell carcinoma cells.

The antimicrobial activity and application of graphene quantum dots in oral medicine / 口腔疾病防治

@#The abuse of antibiotics has been increasing bacterial resistance, which means there is a need to develop methods for the efficient detection and effective treatment of multiresistant bacterial infections. As one of graphene-based materials, graphene quantum dots (GQDs) have distinct mechanical, electrical, and optical properties, including a small size, a large surface area-to-volume ratio, biocompatibility, antimicrobial activity and tunable photoluminescence. Therefore, GQDs are expected to be widely used as antimicrobial materials, drug delivery carriers and photosensitizers in antibacterial applications. In this review, we focus on their synthesis, characteristics and antimicrobial applications in oral medicine.

Research progress of nanomaterials and nanotechnology in cancer radiotherapy sensitization / 口腔疾病防治

@#With the development of nanomaterials and nanotechnology, nanomedicine possesses the vast application prospects in the field of cancer therapy. Although the proportion of radiotherapy in cancer comprehensive therapy is rising, the radiotherapy resistance of cancer cells and the side effects of radiotherapy are the existing problems. Compared with the traditional radiotherapy sensitization, it will present a higher treatment efficiency and lower toxicity to introduce nanomaterials and nanotechnology to cancer radiotherapy. This review elaborates the research of nanomaterials and nanotechnology on cancer radiotherapy sensitization.