Beneficial effects of Antimalarials in the Treatment of Generalized Granuloma Annular in children

Granuloma annulare is a polymorphic granulomatous disease of the skin. It has a chronic course and affects mainly children and young adults. We report two cases of generalized granuloma annulare in children successfully treated with antimalarials.Two children, 6 and 12 years of age, without clinical history, presented with multiple granuloma annulare lesions which did not respond to potent topical steroids. Blood glucose level was normal. These lesions responded to small doses of antimalarials. No side effects were noticed.Compared with other drugs, with potential important side effects for children. Small doses of antimalarials might be beneficial in the treatment of generalized granuloma annulare

[Kaposi's sarcoma, a series of 65 cases]

Kaposi sarcoma [SK] is characterized by proliferation of vascular and spindle-shaped cells with variable clinical presentations. The association with AIDS modifies the profile of this disease. The pathophysiology seems to be based on the major role HHV-8 The goal of this work was to specify the profile of this disease in our region through a retrospective study of 65 cases of SK over a 23-year period [1981-2003]. In our series, the classic form prevailed 163 cases [96.9%]]. One patient had a secondary form due to steroid therapy and another patient had a KS associated with AIDS. A male prevalence was noticed [M/F: 2.8]. Cutaneous lesions were dominated by papulo-nodular lesions [90.9%] of the lower limbs [92.3% of the cases]. Mucous lesions were present in 15.4% of the cases. Therapeutic abstention was decided in 38.4%.Surgical excision was indicated in 35.4% of cases, radiotherapy in 4.6% of the cases and chemotherapy in 23% of the cases. The classic form of KS is the most frequent in our area; the other forms remaining rare