RESUMO
This work aimed to evaluate the role of protein C, some of the coagulation cascade proteins and lipids profile in ischemic heart disease [IHD] and myocardial infarction [MI]. The present study included 40 men selected from ICU Matareya Educational Hospital and classified into 20 cases suffering from ischemic heart disease [IHD group], 20 patients suffering from myocardial infarction [MI group] and a control group comprising 20 healthy normal males. Prothrombin time [IT] prothrombin [P] concentration, activated partial thromboplastin time [APTT], plasma fibrinogen concentration [PF] and protein C [PC] activity were measured in plasma. In serum, creatine kinase [CK], creatine kinase-MB [CK-MB], lactate dehydrogenase [LDH] activities, total lipids [T lipids], phospholipids, triacylglycerol [TAG], total cholesterol [TC], cholesterol-low density lipoprotein [LDL-C] and cholesterol-high density lipoprotein [HDL-C] were measured. The results of the study showed a positive relationship between the levels of plasma clotting factors and hyperlipidemic status, where there may be an interaction between plasma lipoproteins and procoagulant factors. Also, the hypothesis that MoL-C downregulates the thrombin generation via the PC pathway was supported