RESUMO
Esophageal motility studies were conducted on 30 individuals; 20 patients with chronic renal failure [CRF], compared to 10 healthy volunteers. Patients with CRF were divided into 2 groups, [Group I] representing patients on regular haemodialysis [10 patients] and [group II] representing patients on conservative therapy [10 patients].The three groups were age and sex matched.Each group was further subdivided into symptomatic and asymptomatic subgroups according to the presence of symptoms suggestive of esophageal motility dysfunction. Esophageal manometry by Sandhil manometry set was done to all subjects. The results revealed that the lower esophageal sphincter pressure [LESP] was significantly lower in group I [p<0.05] and group II [P<0.001], when compared to the control group III. Group II showed significantly lower level [p<0.05] when compared to group I. The LESP was significantly lower in the symptomatic [p<0.05] than the asymptomatic subgroup of patients in both groups I and II. Regarding the lower esophageal sphincter relaxation [LESR%], there was highly significant difference between both groups of patients I and II [p<0.001] when compared with that of the control group III. At the same time, group I patients showed more significantly lower level [p<0.001] than group II. The amplitude of esophageal body contractions was significantly lower [p<0.05] in group I when compared with that of group II and control group III. While in group II, it showed insignificant change in comparison with that of the control group III [p>0.05]. As regards the velocity of esophageal body contractions in the symptomatic subgroup of group [I], there was a significant increase when [p<0.05] compared with that of the asymptomatic subgroup. Insignificant changes were observed on comparing both groups of patients with the control group and in both subgroups of group II [p>0.05]. The previously mentioned esophageal motor disorders were significantly correlated with decreased serum calcium and increased serum parathormone levels in both groups I and II. So, we could conclude that significant motility disorders were found in patients with CRF, wheather on regular hemodialysis or on conservative measures. However these motility disorders were more, evident in the conservative treatment's group regarding the decrease in the LESP. On the other hand the decrease of the esophageal body pressure was more evident in hemodialysis patients